Das Klinikum rechts der Isar der Technischen Universität München widmet sich mit 1 161 Betten und rund 5 500 Mitarbeitern der Krankenversorgung, der Forschung und der Lehre. Jährlich profitieren rund 60 000 Patienten von der stationären und rund 250 000 Patienten von der ambulanten Betreuung. Das Klinikum ist ein Haus der Supra-Maximalversorgung, das das gesamte Spektrum moderner Medizin abdeckt. Seit 2003 ist das Klinikum rechts der Isar eine Anstalt des öffentlichen Rechts des Freistaats Bayern.
The Department of Medicine II of the Technical University of Munich (TUM) and the Institute of Translational Cancer Research and Experimental Cancer Therapy at TUM and the German Cancer Research Center invite applications for
PhD positions (f/m/d) in Cancer Biology, Immunology and Bioinformatics
at the Center for Translational Cancer Research (TranslaTUM) in Munich.
We are deploying genetic models and bioinformatics including machine learning to study molecular, immunological and translational aspects of pancreatic cancer. One focus in the past few years was the development of novel preclinical models and organoid-based orthotopic transplantation strategies to mechanistically analyze subtypes of pancreatic cancer. The focus of the advertised projects will be on the identification and functional validation of novel therapeutic targets with a focus on tumor cell intrinsic as well as inflammatory pathways that are required for tumour initiation and progression in vivo (e.g. Nature 2018, 554:62-68; Nat. Rev. Cancer 2017 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7; Cancer Cell. 2013,24:15-29, Cancer Cell. 2013,23:406-20, Nat Commun. 2013;4:1630; PNAS 2011, 108:9945-50).
We are a young and enthusiastic team and offer intensive training and mentoring. The successful candidates will have the opportunity to learn a wide spectrum of genetic, molecular and cell biology, biochemical as well as immunological and bioinformatics techniques. They will be exposed to cutting edge methods to study translational aspects of cancer (e.g. Cre / loxP and Flp / frt based dual- and triple recombinase systems, organoid culture, orthotopic transplantations of organoids, CRISPR / Cas9, molecular in vivo imaging, in vivo transposon mutagenesis, RNA and exome sequencing, single cell sequencing, histocytometry). They will also be able to gain insights into clinically relevant aspects of cancer development through proximity to the clinical facilities and through the interdisciplinary composition of our team and closely collaborating groups.
We are looking for self-motivated bright individuals with a Diploma or Masters degree in bioinformatics, biochemistry, biology, molecular / translational medicine or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics or bioinformatics as well interests in molecular aspects of cancer research is essential.
Payment is according to tarif (TV-L). We give priority to severely disabled applicants with essentially equal qualifications.
Please send your application including a letter of motivation, CV, certificates, recommendation letters in one PDF file to Prof. Dieter Saur (e-mail: email@example.com).