Research Unit Molecular Immunoregulation
Area of research:
As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.
The announced PhD position will be located at the Helmholtz Center Munich, which is part of the growing research campus Martinsried / Grosshadern, where for instance also the Biomedical Center (BMC) of the LMU, the Gene Center of the LMU and the MPIs for Biochemistry & Neurophysiology are located. Through our partner lab at the Biomedical Center (BMC) of the LMU, the PhD candidate will have access to additional facilities and collaboration partners.
Our Research Unit ‚Molecular Immune Regulation’ located at the Helmholtz Center Munich-Grosshadern investigates the molecular control of T cell-mediated immune responses and is offering a
The PhD project will focus on the development of novel strategies to improve cancer immunotherapies. To ensure appropriate immune responses the activation and differentiation of T cells is tightly controlled by posttranscriptional regulators like Roquin and Regnase-1, which influence mRNA stability (Jeltsch et al. Nature Immunology 2014 and Vogel et al. Immunity 2013). Based on this knowledge the aim of the new project is to analyze, how these posttranscriptional regulators influence CD8 T cell effector function and survival using in vitro and in vivo approaches.
The PhD project is interdisciplinary in nature and involves:
- Immune cell phenotyping by multicolor flow cytometry
- Primary T cell culture work
- Molecular biology
- Mouse tumor models
- Adoptive cell transfer experiments
- Very good marks in Biology, Biochemistry or related disciplines
- Good practical and theoretical background in Immunology
- Interest in studying the tumor immune responses of mice
- Good expertise in cell culture, molecular biology and genetics
- The ability to work self-motivated in an international team
- Good skills in written and spoken English
- Willingness to work with mice
At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services.
Remuneration and benefits are in accordance with the collective agreement for the public service (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled.
The position is (initially) limited to three years.
The activity involves special knowledge and experience specific to own scientific skills.
As a holder of the Total E-Quality Award, we promote equality of opportunity. Applications from women are welcome. Qualified applicants with physical disabilities will be given preference.
We are looking forward to receiving your comprehensive online application until December 31th 2018.