- Job Ref: MI/18/88
- Salary within the range of £31,604 – £41,929 per annum (depending on qualifications and experience)
- Duration: Fixed term for 3 years
About the role:
Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is looking for a Postdoctoral Scientist to join his group. This is a great opportunity for a self-motivated, innovative, meticulous and organised candidate with excellent communication skills to work in a dynamic laboratory undertaking cutting edge research.
The goal of the Systems Oncology Group is to understand how aberrations in cellular signalling affect tumour progression. In particular, we are interested in understanding how signalling between cancer cells and cells in the tumour microenvironment promote tumour progression and drug resistance. Using global approaches such as proteomics, mass cytometry, CRISPR and RNA sequencing we aim to identify and understand the mechanisms of cell-cell communication (Tape et al Cell 2016, Jorgensen et al Science 2009, Tape et al Mol Cell Proteomics 2014, Tape et al Anal Chem 2014, Worboys et al Nature Methods 2014). This role is an exciting opportunity to join a multidisciplinary team to study these problems.
You will develop a research project with the aim to address how stromal cells regulate tumour cell signalling, and in particular how tumour cells integrate multiple co-occurring signals. Successful implementation of approaches to study transient protein interactions, and their post-translational modifications, is critical to the success of this project. This project requires extensive use of mass-spectrometry based proteomics, and you are expected to be competent in a full range of biochemical techniques and various proteomics workflows including quantitative proteomics and analysis of post-translational modifications. You will be expected to interact with members in the laboratory and contribute to the design and development of on-going research projects in support of the Systems Oncology group.
You should have a PhD in biochemistry, chemistry or a relevant field. Experience in protein biochemistry and MS-based proteomics is essential to the success of the project. Key qualities should include independent thinking, ability to work in a team and good communication skills, all of which are needed to efficiently work in a multidisciplinary team.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside.
We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes.
How to apply?
To apply for this position please visit our website: http://www.cruk.manchester.ac.uk/Opportunities/Opportunities-Home
Informal enquiries can be directed to Dr Claus Jorgensen via email: claus.jorgensen@ cruk.manchester.ac.uk.