Institute Sr Research Scientist - Flow Cytometry - ECLIPSE

Institute Sr Research Scientist - Flow Cytometry - ECLIPSE

MD Anderson Cancer Center

Houston, TX, United States

ECLIPSE is a new platform at The University of Texas MD Anderson formed to identify novel cancer antigens and develop biologic immunotherapy strategies to treat leukemias. The primary requirement for an individual in this position is an experienced and highly motivated scientist with hands-on experience in generation and analyses of complex multi-parametric flow cytometry data. Such data is expected to influence a broad array of decisions around target identification and validation. The successful candidate will participate in cross-functional research and to design, perform and interpret assays for high throughput and high-content flow cytometry analyses. The candidate must have solid hands-on experience with designing high-parameter and high-throughput flow cytometry assays and executing robust computational analyses of longitudinal primary cell analyses on various software platforms used in flow data analyses. A strong background in T cell immunology, leukemia and stem cell transplantation is critical to success in this position. The selected candidate will be expected to work at the bench and also manage direct reports. The candidate will be expected to participate in platform leadership and decision-making. Previous experience in biotech/pharma is highly preferred. Experience with the FACS Symphony instrument and cell sorting experience would be beneficial.

The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

Salary range: Min $112,000 - Mid $140,000 - Max $168,000


•Coordinate multidimensional flow cytometry evaluation from cells of patients with advanced hematological malignancies.

•Provide expert technical guidance in flow cytometry assay design, development, set up, trouble shooting, validation and implementation to others on project/task groups. The candidate will be responsible for driving research programs in a multidisciplinary and exciting research team environment and supervise research activities of direct reports.

•The successful candidate will approach problems with curiosity and open mindedness; notice current processes/products needing improvement and generate new options using own technical expertise.

•Oversee development and quality of flow cytometry data generated both internally and externally.

•Lead cytometry data analysis strategies in coordination with the platform informatics group.

•Ensure scientific excellence, quality and completeness of programs in a timely manner.

Required: Master's degree in one of the natural sciences
Preferred: PhD in Biochemistry, Immunology or a related discipline.

Required: Eleven years of relevant research laboratory experience. With preferred degree, five years of required experience.

Preferred: At least ten years of relevant research experience in the lab with supervisory experience in guiding direct reports.

•Demonstrated expertise in designing and performing multi-parametric complex flow cytometry assays; and acquisition/analysis of its data.

•Expertise in ensuring instrument standard operating procedures and maintenance of high value flow cytometry instruments.

•Experience in maintaining quality control, assuring compliance with regulations and standards of regulatory agencies, and managing special projects.

•In depth knowledge of commercial flow cytometry software including BD FACS Diva, FlowJo, FCS Express, Cytobank, TiSNE and unbiased data analyses approaches.

•Experience in using and maintaining flow sorting instruments.

•Significant experience managing a diverse team in high pressure situations.

•Ability to clearly communicate and operate in a highly matrixed environment.

•Proven track record of handling multiple high priority tasks in parallel with internal and external collaborators.

•Ability to provide subject matter guidance and train junior personnel in cytometric experimental and panel design, set up and data analysis

•Hands on experience working with primary hematological samples, with working knowledge of basic molecular biology techniques.

•Extensive knowledge in key areas of flow cytometry, including knowledge of recent developments in flow cytometry methodologies as evidenced by publication in peer-reviewed journals.

•A strong understanding of flow cytometry theory and application in routine analysis

•Experience in single cell sorting for downstream genomic and transcriptomic analyses.

•Team player with outstanding communication skills and ability to interact with both internal and external collaborators.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.

Additional Information
  • Employee Status: Regular
  • Minimum Salary: US Dollar (USD) 112,000
  • Midpoint Salary: US Dollar (USD) 140,000
  • Maximum Salary : US Dollar (USD) 168,000

Please apply via recruiter’s website.

Quote Reference: MD Anderson-md_anderson-4432_122130