Nuffield Division of Clinical Laboratory Sciences, University of Oxford

Oxford, South East England, United Kingdom

Salary: Grade 6: salary in the range £28,660 - £34,189 p.a. Grade 7: Salary in the range £32,236 - £38,460 p.a.

Applicants are invited for a Researcher position at the Nuffield Division of Clinical Laboratory Sciences (Radcliffe Department of Medicine) - University of Oxford. We wish to appoint at Grade 6 (salary in the range £28,660 - £34,189 p.a.) or 7, depending on your qualifications and experience.

The Bloodwise Molecular Haematology Unit undertakes genetic and functional analysis of the myelodysplastic syndromes (MDS), a myeloid malignancy. The focus of the research project is the investigation of the role of splicing factor gene mutations in MDS, including the impact of these mutations on pre-mRNA splicing and the effects of spliceosome inhibitors. The project involves the application of a number of techniques to the study of MDS, including next-generation sequencing and cell culture (using lentiviral constructs). Further details are provided in each job description.

The Grade 6 appointment would be suited for an individual with an MSc in a relevant subject, research experience of molecular biology of cancer, cell culture and lentiviral transduction as well as experience in global gene expression profiling, as well as at least one publication in a peer-reviewed journal. Among your duties, you will perform experiments associated with the research project (such as NGS and data analysis, cell culture and lentiviral transduction, gene expression profiling) and assist with the processing of blood and bone marrow samples.

The Grade 7 appointment would be suited for an individual with a PhD in a relevant academic field, research experience in molecular biology of cancer (inc. DNA sequencing), cell culture and lentiviral transduction as well as experience in global gene expression profiling, and at least one first-author article in a leading refereed journal. The appointee will drive the project forward and perform all the required experiments. These include functional studies in vitro to determine the impact of the common spliceosome mutations on myeloid and erythroid cell growth and differentiation in MDS and to assess whether the presence of these mutation accounts for some of the cellular defects characteristic of particular MDS subtypes. He/she will analyse and interpret data, and is expected to provide substantial input for writing reports and papers.

This position is available full-time, fixed-term from 10 January 2019 until 31 July 2019. Given the relatively short duration of the contract, it is not expected that an appointment at Grade 6 would progress to Grade 7.

Candidates are encouraged to discuss their needs and preferences for work arrangements at interview. Applications for this vacancy are to be made online. For further details, including a job description and person specification, please see below.

The closing date for applications is 12.00 noon on 19 November 2018 and interviews will be held on 10 December 2018.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-137665