Postdoctoral Position, Niethammer Lab, MSKCC, NYC
Illuminating Signal 0 of Tissue Inflammation, Healing, and Regeneration in Zebrafish
To heal and regenerate, tissues must first “know” that they are injured. How wound detection occurs is unclear, but if it malfunctions, infection, allergic disease, fibrosis, or cancer may result. Our lab investigates the triggers and mechanisms of wound detection. The ultimate aim of our research is to block or unlock this process during disease, for example, to stop vicious auto-inflammatory circles at the doorstep or turn immune cells against tumors.
We study the wound detection using an interdisciplinary approach that utilizes artificial membrane systems, microfluidics, cultured cells, and intravital imaging in zebrafish (e.g., Niethammer et al., Nature, 2009; Enyedi et al., Nature Cell Biology; 2013; Enyedi et al., Cell, 2016; Huang et al., Immunity, 2018).
Available project areas include:
• The biomechanical regulation of early inflammation during wound detection and confined leukocyte migration in tissues.
• Inflammatory lipid signaling during wound healing and cancer.
• Visualizing physiological gradients of inflammatory mediators during tissue damage and infection.
We are a young, interdisciplinary team that embraces new ideas, approaches, and rigorous, quantitative research. Candidates from cell biology, bioengineering, biophysics, biochemistry, immunology are encouraged to apply. Experience with zebrafish is not required. Own ideas are welcome to start a discussion.
The position is suited for versatile, goal-oriented candidates who enjoy interdisciplinary work, quantitative approaches, and want to answer basic biological questions in a biomedically relevant context, and in intact animals.
o Initial funding is covered for at least two years. Generous MSKCC postdoctoral fellowships are available for productive candidates.
o Subsidized Manhattan housing is available for at least three years.
o Salary levels are competitive.
o Ample career development opportunities are available.
o The MSKCC-Rockefeller University-Weill Cornell Medical College triangle campus is a thriving biomedical community, comparable in density and intensity to Harvard and MIT. But it is New York City—so we win!