Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term (4 years), full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 8966
A postdoctoral research post in the laboratory of Max Gutierrez is now available. We are looking for a highly motivated researcher to develop human stem cell derived cells (iPSC) cellular systems to investigate the innate immune response to Mycobacterium tuberculosis. As part of this project you will be developing CRISPR/Cas9 engineered human stem cells in 2D/3D micro-fabricated physiological environments. This research is part of a recently funded ERC consolidator grant that aims to develop better models of human cells and tissues to understand the interplay between host cell and pathogen in tuberculosis. The successful applicant will use a wide range of techniques such as high content live cell imaging, correlative light electron microscopy and human stem cell genome editing. For more information about our research, please visit the external lab website: Gutierrez Group. The successful applicant will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion).
In this project, we will develop cellular systems that combines CRISPR/Cas9 engineered human stem cells and 2D/3D micro-fabricated physiological environments for single cell analysis. We will use these cellular systems together with technologies developed in our group to image and quantify Mtb localisation and replication, such as live cell imaging and correlative live cell 3D- electron microscopy (CLEM). Moreover, we aim to refine these approaches to challenge the current limits of cell-based, high content imaging. This research is part of a recently funded ERC consolidator grant that aims to develop improved models of human cells and tissues to understand the interplay between host cell and pathogen in tuberculosis.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 21st November at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.