Location: The Francis Crick Institute, Midland Road, London
Contract: Permanent, full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 8926
We are a young, dynamic and multidisciplinary team developing a method that allows the direct observation of biochemical processes at atomic spatial- and milliseconds time-resolution by combining microfluidics and cryo-electron microscopy (cryo-EM). We utilize microfluidics devices to mix and incubate biochemical samples on sub-second time scales and then rapidly spray-plunge-freeze the reactants for subsequent three-dimensional structure determination by cryo-EM. In this way we can produce molecular movies visualising biological macromolecules during binding or catalytic events in great detail. We are applying this technique, alongside structural biology, biophysical and biochemical methods to answer fundamental biological questions in the fields of ubiquitin signalling and DNA damage repair.
This is an exciting opportunity to perform high risk and cutting edge research in a truly multidisciplinary environment by supporting the group and collaborative projects with:
- Design, production and optimization of microfluidic devices (e.g. by photolithography, 3D printing, CFD simulations)
- Data collection and analysis by single particle cryo-electron microscopy
- Basic molecular biology work (e.g. cloning and protein production)
The ideal candidate should have a PhD and extensive work experience and strong track record in at least a couple of the above and a proven ability to collaborate and to train junior members of staff.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 21 November 2018 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.