The Institute Associate Scientist III – Functional Genomics participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients.
The mission of The Center for Co-Clinical Trials (CCCT) is to integrate biological insights with drug discovery expertise to accelerate the development of innovative targeted cancer therapeutics. The CCCT is a ground-breaking translational research team that partners with world-class drug discovery scientists at the Institute for Applied Cancer Science (IACS) along with their industry-modelled in vivo pharmacology unit and state-of-the-art computational biology infrastructure. CCCT's cross-functional teams aim to deliver biological insights regarding genetic and functional contributions that influence tumor response to novel therapeutic agents or regimens. As part of the MD Anderson Cancer Center Moon Shots initiative, the capabilities of the CCCT, in concert with IACS, support the institution's academic and clinical research programs to help us reach our goal of delivering safer, more effective treatments to our patients.
1. Under minimal supervision contribute to project team activities through laboratory experiments.
2. Contribute to project team's target discovery, validation and drug discovery efforts.
3. Utilize common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies to support target validation and drug discovery programs.
4. Perform common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines.
5. Utilize siRNA, inducible shRNA, CRISPR, dominant negative methods, and small molecule inhibitors to validate targets and biomarkers.
6. Assist in the development and utilize molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays to support target validation and/or drug discovery programs.
7. Perform dose response studies in support of patient stratification and biomarker development.
8. Provide support for in vivo pharmacokinetic, pharmacodynamic and efficacy studies for target validation and drug discovery efforts.
9. Assist in analysis of in vivo samples for assessment of pharmacodynamic biomarkers.
10. Help establish and validate mechanistic and functional cell based studies for evaluating novel therapeutic targets.
11. Employ safe lab practices.
12. Maintain research records and laboratory notes
- Employee Status: Regular
- Minimum Salary: US Dollar (USD) 48,000
- Midpoint Salary: US Dollar (USD) 88,800
- Maximum Salary : US Dollar (USD) 129,600