Institute Research Investigator - In-Vivo Pharmacology ORBIT
MD Anderson Cancer Center
Houston, TX, United States
Posted about 2 days agoExpires on April 23, 2019
ORBIT (Oncology Research for Biologics and Immunotherapy Translation) is a novel organization within the MD Anderson Cancer Center, Houston, Texas, with the mission of making MDACC a recognized leader in the discovery and development of innovative biologics that help patients to prevail over cancer disease. ORBIT is a centralized MDACC organization that will guide, inform, accelerate and execute the translation of novel discoveries into clinically relevant cancer bio-therapeutics. We are committed to biologics development with industry standard and aim line of sight for combining scientific excellence with commercialization.
The successful candidate will join the in vivo group efforts in the characterization and development of monoclonal antibodies including those that function as immune modulators for the treatment of cancer. S/he will contribute to the pharmacology and toxicology (in vitro, ex vivo and in vivo) studies for multiple research programs across the different stages of pre-clinical drug discovery. Experience in the pharmaceutical or biotech industry is preferred.
•Under minimal supervision, perform in vivo studies for target validation, drug efficacy, PK/PD/efficacy relationship in the area of oncology and tumor immunology.
•Under minimal supervision to develop new in vitro assays and contribute to the ex vivo analysis of tumor or immune cells by FACS, IHC, ELISA, western blot to identify and validate biomarkers and elucidate MOA in vivo.
•Independently plan, execute, analyze, and document experiments, manage multiple in vitro/in vivo/ex vivo experiments simultaneously.
•Comply with regulatory requirements and IACUC protocol implementation.
•Work in a team environment and, as needed, train new personnel hands-on.
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: PhD degree in related field
Required: Six years experience of relevant research experience in lab. With preferred degree, four years of required experience.
•5 years of hands-on laboratory experience in industry, or equivalent.
•Hands-on experience performing in vivo studies, preferably with small molecule drug candidates or biologics, using multiple dose routes (IV, PO, SC, IP), tissue sample collection, and evaluating PD endpoints. Previous experience in cancer biology.
•Organized, self-motivated, able to multitask and deliver results with high degree of attention to detail to drive projects forward in a timely manner.
•Excellent written, verbal communication and presentation skills.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Employee Status: Regular
Minimum Salary: US Dollar (USD) 48,000
Midpoint Salary: US Dollar (USD) 88,800
Maximum Salary : US Dollar (USD) 129,600