School of Biological Sciences
Location: Highfield Campus
Salary: £30,395 to £37,345
Full Time Fixed Term (14 Months)
Closing Date: Friday 16 November 2018
Fixed Term Contract-14 Months
The Inositide laboratory
We are looking for a Research Fellow to investigate how phosphoinositide signalling in the nucleus impacts on the epigenetic regulators to modulate transcriptional output.
Southampton University and Biological Sciences.
Southampton University is a world leading research university with 97% of its research work assessed as world leading and internationally excellent in the REF 2014 assessment. UOS is a Russell group member and its research impacts on government policy making, health issues, teaching and on business.
The work will take place at the main University campus, in Building 85, which houses Biological Sciences researchers and those who conduct multidisciplinary research in any aspect of life sciences. This has led to the establishment of the Institute for Life Sciences (IfLS), highlighting the commitment of Southampton to research in the biological sciences. Biological Sciences houses the Centre for Imaging, which is equipped with state of the art facilities for wide field, confocal and deconvolution imaging enabling live cell fluorescent imaging, FRET and FLIM analysis. It also encompasses the Centre for Proteomic Research, with state of the art technologies and methodologies for mass spectrometric enabling quantitative label free as well as ITRAQ analysis. The interdisciplinary centre for NMR offers the ability to collect data at both 600MHz and 400MHz in both solution and solid state and covering a multitude of nuclei. The facility routinely carries out work on small molecules, proteins, membrane systems and solid samples. Furthermore, it forms part of the wider core facilities aimed at comprehensive solutions to investigate protein structure, providing a biomolecular analysis suite as well as comprehensive facilities for protein crystallisation and structure analysis. Next generation sequencing and bioinformatics analysis are carried out in a new facility housed at the National Oceanography Centre.
This research study is intended to investigate how a family of signalling lipids called phosphoinositides are regulated in the nucleus in response to environmental stimuli and how this impacts on cell behaviour by regulating specific proteins that are involved in epigenetic signalling. The PDRA will collaborate with a technician dedicated to this project to use state of the art molecular technologies such as CRISPR CAS and imaging studies to understand how phosphoinositides impact on the function of specific epigenetic signalling proteins that modulate histone methylation.
The applicant should have experience in epigenetic signalling. Computational knowledge of the analysis of genomes and epigenetic modifications would be useful as would experience in microscopy.
This post is suitable for biochemists and cell biologists with an interest in epigenetic regulation.
Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon successful completion of the PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.
For additional information/informal enquiries before submitting your application, contact Nullin Divecha (firstname.lastname@example.org).
In your application please include a covering letter and full CV and arrange for two letters of recommendation to be sent to Professor Nullin Divecha (email@example.com).
You should submit your completed online application form at https://jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Sam Stubbs (Recruitment Team) on +44 (0)23 8059 4046. Please quote reference 1067818BJ on all correspondence.