Postdoc Associate – (Biochemist/Structural Biologist) DNA Repair

Postdoc Associate – (Biochemist/Structural Biologist) DNA Repair

University of Florida

Gainesville, FL, United States

Job description

The Caglayan lab in the Department of Biochemistry and Molecular Biology, University of Florida seek a Postdoctoral Associate with an experience in Biochemistry and Structural Biology. The NIH-funded research project will focus on studying genomic stability, oxidative stress-induced DNA damage processing, and DNA repair. For more information, please see the lab website at

The Caglayan group is in both the Department of Biochemistry and Molecular Biology, and UF Health Cancer Center with investigators renowned for their contributions to the area of biochemistry and cancer biology. This exceptional training environment offers a highly supportive and collaborative scientific experience in many diverse areas of expertise.

Duties will include

Supporting projects through original research, collaboration with other team members, interpreting and critically evaluating primary literature; collection and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook; preparing and editing manuscripts for publication as well as applications for grants; attending an annual meeting to disseminate research findings and progress; supervising and training of graduate students (PhD and Master’s level) and undergraduates. Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.

Minimum Requirements

PhD, MD, or PhD/MD degree in a related discipline.

Preferred Qualifications

The candidate should have experience in biochemistry and/or structural biology. Previous working experience with evidence of experimental skills related to X-ray Crystallography and/or Cryo-EM is preferred.

Advertised Salary

The salary for this position is commensurate with experience as determined by NIH guidelines. Though the position is fully funded, the successful candidate will be mentored and encouraged to apply for additional financial support.

Selected Publications

1. Caglayan M. and Wilson S.H. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals a promutagenic DNA intermediate during double strand break repair. Nature Communications (2018) 9: 4213.
2. Caglayan M., Prasad R., Krasich R., Longley M.J., Kadoda K., Tsuda M., Sasanuma H., Takeda S., Tano K., Copeland W.C., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088.
3. Caglayan M., Wilson S.H. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research (2017) 1093: 1 – 5.
4. Caglayan M., Horton J.K., Da-Peng D., Stefanick D.F., Wilson S.H. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045.
5. Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (2015) 35: 85 – 89.
6. Caglayan M., Horton J.K., Prasad R., Wilson S.H. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research (2015) 43: 2271 – 2281.
7. Caglayan M., Batra V.K., Sassa A., Prasad R., Wilson S.H. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nature Structural and Molecular Biology (2014) 21: 497 – 499.

Application Instructions

All applicants must also apply through the Careers at UF posting.
Review of applications will begin immediately and will continue until the position is filled.

Please apply via recruiter’s website.

Quote Reference: 55560