The Kubicek laboratory at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, is recruiting a highly motivated Research Technician working on the interface of cell biology, epigenetics and chemical biology.
The Project: The successful applicant will work as part of an ERC-funded team to systematically explore the role of small molecule metabolites in the cell’s nucleus to control chromatin structure and gene expression. This project is based on our recent findings of novel pathways phenocopying BRD4 inhibition (https://www.biorxiv.org/content/early/2018/10/10/439422, Sdelci et al. Nat. Chem. Biol. 2016) and of synthetic lethality in cancer cells (Licciardello et al. Nat. Chem. Biol. 2017).
We use a variety of techniques of functional analysis and detailed molecular characterization of chromatin pathways in cancer, including proteomics, metabolomics, transcriptomics, and epigenomics, as well as chemical and genetic screening.
The Candidate: The successful candidate will have a degree in either biology or chemistry (MTA, CTA, B.Sc., M.Sc., Mag., DI) and previous experience with molecular, cellular or chemical biology, biochemistry and epigenetics. Expertise in genome editing, small molecule probe development, metabolomics, functional screening or bioinformatics is considered a plus. The working language at CeMM is English, and excellent written and oral communication skills as well as high accuracy, reliability and excellent interpersonal and organizational skills are a requirement.
The Laboratory: The Kubicek laboratory is working on the role of chromatin in the definition of cell types and cell states, and the use of chemistry to modulate epigenetic states. The ERC-funded project “Chromabolism” focuses on a systematic understanding of the role of chromatin-bound central metabolic enzymes in the regulation of gene expression.
Recent publications include the first single-cell transcriptomes from primary human pancreatic islets (Li et. al EMBO Rep. 2016), the identification of artemisinins as compounds impacting alpha cell identity (Li et al. Cell 2017), novel functional screening for chromatin states (Sdelci et al. Nat. Chem. Biol. 2017) and synergistic drug combinations (Licciardello et al. Nat. Chem. Biol. 2017). Furthermore, the laboratory hosts the Platform Austria for Chemical Biology PLACEBO, a unique chemical screening infrastructure with a collection of 90,000 small molecule compounds. In a unique automated setup, the platform conducts up to 40 high-throughput screens in collaboration with internal and external researchers. In addition, we
Ce–M–M– Forschungszentrum für Molekulare Medizin GmbH der Österreichischen Akademie der Wissenschaften
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apply proteomics, metabolomics, chemistry, mass spectrometry, bioinformatics, and next generation sequencing to address our research questions. The selected candidate will have the opportunity to work in an innovative research environment and collaborate closely with other groups at CeMM.
The Institute: CeMM is a biomedical flagship institute in the heart of Europe, Vienna. We are committed to highest scientific standards and provide an international environment representing approximately 40 nationalities. The working language is English. CeMM has been ranked by The Scientist as one of the Best Places to Work Academia worldwide (link: http://goo.gl/51VMO). In the past 3 years CeMM groups published numerous ground-breaking studies in prestigious journals such as Science, Cell, Nature, New England Journal of Medicine, Nature Immunology, Immunity etc. CeMM is located within the medical campus of Vienna and operates several technology platforms (chemical biological screening, proteomics, metabolomics, next-generation sequencing) as well as extensive bioinformatics infrastructure.
Your Application: Interested candidates are encouraged to upload their application documents (including a cover letter, and a CV) online. Please upload your full application here: https://cemm.jobbase.io/job/4jnfk8x1 Applications will be reviewed on a rolling basis until the position is filled.