As one of Europe’s leading research universities, Ludwig-Maximilians-Universität (LMU) in Munich is committed to the highest international standards of excellence in research and teaching. Building on its more than 500-year-long tradition, it offers a broad spectrum that covers all areas of knowledge within its 18 Faculties, ranging from the humanities, law, economics and social sciences, to medicine and the natural sciences.
Research interests of the Siegel Lab:
The goal of our research is to understand the molecular mechanisms underlying antigenic variation. We are specifically interested in how changes in chromatin structure and 3D genome architecture affect antigen expression at the single-cell level. To study these questions, we use Trypanosoma brucei, a unicellular parasite that causes human sleeping sickness in Sub-Saharan Africa.
Using numerous system-wide approaches (ribosome-profiling, high-resolution ChIP-seq, single cell RNA-seq, ATAC-seq, Hi-C) as well as CRISPR-Cas9 and state-of-the-art microscopy, we study how different chromatin structures are established at specific loci along the genome, how they are formed across the nucleus in three dimensions and how they affect gene expression.
For recent publications from our lab see:
• Wedel et al. EMBO J, 2017. https://doi.org/10.15252/embj.201695323
• Vasquez et al. NAR, 2018 https://doi.org/10.1093/nar/gky517,
• Müller et al. Nature, 2018 https://doi.org/10.1038/s41586-018-0619-8
Our group is located at the newly built Biomedical Center (BMC) of the LMU. Our group is funded by grants from the the ERC, DFG, the Clusters of Excellence CIPSM and the Humboldt Foundation. Numerous in-house core facilities ensure access to state-of-the-art equipment. Further information can be found at: www.siegel-lab.de and http://www.en.bmc.med.uni-muenchen.de/index.html
PhD candidates are expected to be highly motivated, to have good verbal and written English skills and to enjoy working on challenging research projects.
In addition, postdoc candidates are expected to have a strong background in gene regulation, chromatin biology, biochemistry or molecular biology and expertise in one of the following areas:
• Fluorescence super-resolution microscopy
• Single-cell biology
The successful candidate will have the opportunity to collaborate with NGS experts and infection biologists.
The salary will be based on TV-L 13. The contract will be for 3 years and can be extended.
How to apply:
Please send your application (motivation letter, CV, names of two referees and transcripts in one PDF) citing “18/10” in the subject line by email to email@example.com. The call will remain open until November 30th 2018 or until the position is filled.
The Ludwig-Maximilians-Universität is an Equal Opportunity Employer. In case of equal qualification, disabled persons will be preferentially considered.