Functional validation of mutations in innate immune pathways that cause pediatric autoinflammatory disease.
Dr. Seth Masters, Professor, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Hospital, Sun Yat-Sen University.
Laboratory Head, Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Hospital, Sun Yat-Sen University
Guangzhou, China PRC
September 15, 2018
December 01, 2018
Postgraduate – PhD
1. Project Details
Mutations in innate immune pathways can cause serious inflammatory diseases in children (autoinflammatory diseases). In this project we have applied exome sequencing technology to identify novel mutations that cause these diseases. We will now perform functional validation of the mutations using cell biology assays of inflammation and inflammasome activation using CRISPR and other approaches. For recent examples, please see https://www.ncbi.nlm.nih.gov/pubmed/30038614 and https://www.ncbi.nlm.nih.gov/pubmed/29778503.
This project will be conducted within the Guangzhou Institute of Pediatrics (GIP), affiliated with Guangzhou Women and Children’s Medical Center (GWCMC). The primary supervisor will be Professor Dr. Seth Masters.
All candidates who have expertise in the following disciplines are encouraged to apply: genetics and genomics, biochemistry, cellular and molecular biology, immunopathology. Ideal candidates should be highly motivated, collaborative, and have hands-on experience in a related scientific field.
- Fresh PhD graduates from domestic or overseas high-level universities or research institutes
- Candidates with age below 35
- Demonstrated ability to work independently
- Have good communication skills
3. Salary and Benefits
Basic annual salary: $35,000-$40.000
Incentive Award: Depending on success in securing grant support and productivity in research work.
Benefits: Full benefits including vacation, insurance
4. How to Apply
Applications including a full CV, the name and email address of three referees, and a personal statement should be sent to firstname.lastname@example.org
In the subject of the email, please refer to “GIP-innateimmunity”.