We seek to recruit a highly motivated postdoctoral fellow in Prof Derumeaux’s Lab at the Mondor Institute of Biomedical Research (IMRB, Créteil, France) to explore cardiometabolic and immunological mechanisms susceptible to modulate pathological organ/tissue and cellular aging associated with a variety of high prevalence metabolic disorders, such as type 2 diabetes and obesity.
Accelerated cellular senescence affecting key tissues and cell types is currently thought to be a major pathophysiological contributor involved in many chronic disorders, its role being very actively investigated. Yet, still very little is understood about the specific relevance of cellular senescence processes for the context of metabolic disorders, and in particular for the development of deleterious cardiovascular complications associated with them, as well as the precise molecular mechanisms underlying their involvement.
Our work is focused on exploring cellular senescence mechanisms in a variety of tissues and cell types, known to play a central role in metabolic disorders pathophysiology, including the myocardium, the adipose tissue, the liver, the skeletal muscle, as well as various types of circulating or tissue resident immune cells. In addition to multiple metabolic and functional experiments used to investigate these processes, we are currently analyzing the role of immune cells both in animal and human models, aiming to explore the molecular mechanisms and the specific modalities of cellular/tissue aging in a variety of conditions including diabetes, calorie rich diets, physical exercise, exposure to pollutants, etc.
These studies are coordinated by Dr D. SAWAKI, associate professor at Paris-East Medical School, and benefited from the support and expertise of the CARMMA project coordinated by Prf. Genevieve DERUMEAUX, also with skills and knowledge from local, domestic and international collaborators.
Some of the areas currently under investigation include:
1. Specific changes of the immune cellularity, characters in key cell types (monocyte/macrophage, T-lymphocyte, ICLs, etc) involved during physiological aging and cardiac and metabolic pathology, focusing on phenotyping cellular senescence and its relevance on cellular function.
2. Modulation of age related tissue remodeling (cardiac and metabolic organs) mediated by immune cells under different metabolic conditions and interventions (diet, exercise, exposure to pollutants, etc.)
3. Development of rescue interventions such as bone marrow transplantation (BMT), treatment with senolytic agents with special packaging
4. Identifying early predictors in circulating immune cells associated with the propensity of developing certain cardiovascular complications associated with metabolic disorders, including various forms of dysmetabolic cardiomyopathies
Applicants must be curious, highly motivated, have demonstrated the ability to design and carry out creative, independent research, and have excellent communication skills using the English language and demonstrated scholarship through publications in internationally recognized English language journals.
Our team is affiliated with INSERM (French National Health Institute) and is located at Mondor Institute of Biomedical Research (IMRB) on the campus of Paris-East Medical School in Creteil, south-east of Paris, just outside of the city. We have recently initiated a 5-year, 10 million euros program, aiming to explore “Cardiac and skeletal muscle alteration in relation to metabolic diseases and ageing” (CARMMA), involving several French and European research labs and biotech companies, and coordinated by Prof G. Derumeaux. Paris-East Medical School and the IMRB are hosting a large number of research teams and facilities and are a great place to do science (http://www.imrb.inserm.fr/en/). Inside our facility, we have close collaborators in the field of Liver disease (Prf. J-M Pawlotsky, Dr. F Clerc), immunology (Prf Y Levy, Prf. S Hue) and cellular metabolism (Dr. R Motterlini) with a tremendous amount of experience and knowhow in exploring the multiple dimensions that characterize tissue/cellular immunity.
Minimum degree and field of knowledge: PhD or MD PhD in immunology, molecular biology, or related fields is required, with a strong publication record in these areas. An ideal candidate would have extensive experience in FACS preparation/staining/sorting and data analysis, as well as a minimum level of expertise in molecular biology and animal work.
Specific expertise in macrophage/lymphocyte biology, harvest and culture technique and bone-marrow transplantation skills would be very valuable. This opening is an ideal opportunity for recent MD PhD and/or PhD graduates oriented towards a career in medicine and/or biomedical research. Interested candidates should submit a CV, a brief statement of current and future career goals and contact information for three references by email to firstname.lastname@example.org or email@example.com. The position is available now, in agreement with INSERM’s specific regulations on these matters.