Postdoctoral Fellow – Statistical Geneticist/Computational Biologist
Salary in the region of £31,503 – £39,492 (dependent on experience) plus excellent benefits
Fixed term for 3 years
We are looking for two enthusiastic and highly-motivated statistical geneticists/computational biologists to join the Immune Genomics group as postdoctoral fellows. The group is led by Gosia Trynka and we are a part of the Cellular Genetic and Human Genetics Programmes at the Wellcome Sanger Institute.
We are seeking someone with strong statistical and computational skills who is interested in working with large scale genomic datasets to perform integrative analysis and develop their own statistical methods. We are looking for someone with experience in analysis of functional genomics assays, such as RNA-seq, ChIP-seq, Hi-C and single cell RNA-seq. We are looking for someone creative, who will engage with ongoing research projects as well as demonstrate independent thinking and shape the future research questions in the lab. You will be supported to develop your own research projects within the scope of the group’s interests.
Join our group in the efforts to understand the genetic basis of immune-mediated diseases. We combine large scale experimental and computational work to uncover the genetic regulation of the human immune system. We use immune assays where we challenge cells in different conditions and measure a variety of cellular processes. The backbone to all our cellular readouts is a rich palette of genomic assays which we use for profiling gene expression regulation and chromatin activity in bulk and at the single cell level. These approaches allow us to link genetic variants to immune cell functions and ultimately to connect to impaired disease processes.
• PhD in genetics, molecular biology, computational biology, statistics and relevant subject area
• Strong understanding of statistics, genetics and quantitative genomics
• Demonstrated experience working with genomic data
• Proficient programming skills (e.g. Python, Perl, R)
• High self-motivation and critical thinking skills
• Ability to communicate ideas and results effectively
• Ability to work independently and organise own workload
• Excellent written and spoken English
• Experience writing scientific manuscripts
• The ability to effectively communicate with collaborators and occasionally present orally to large groups
• Proven independent working style, problem solving, data analysis and generation of novel ideas.
The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.
Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
• Group Defined Contribution Pension Scheme and Life Assurance
• Group Income Protection
• Private Health Insurance
• 25 days annual leave, increasing by one day a year to a maximum of 30
• Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
• Two days paid Employee Volunteering Leave a year
• Employee Discount Scheme
• Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
• Active Campus Sports and Social Club
• Free Campus Bus Service
Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.
Please include a covering letter and CV with your application. Closing date: 4th November 2018