Postdoc position on co-operative oncogenic events in acute lymphoblastic leukemia

Postdoc position on co-operative oncogenic events in acute lymphoblastic leukemia

KU Leuven

Leuven, Belgium

The laboratory for Disease Mechanisms in Cancer (Department of Oncology, KU Leuven) is looking for a motivated postdoctoral researcher. Our team has a long-standing interest in studying the biology of acute lymphoblastic leukemia (ALL), and in particular we focus on the role of mutations in ribosomal proteins and their association with other mutations in ALL. Accumulation of mutations in ALL does not occur randomly, and particular lesions show significant co-occurrence or mutually exclusivity in the leukemia cells. This project aims at studying the molecular biological mechanisms by which co-occurring oncogenic events in T-cell ALL cooperate with each other to drive leukemia development, and how this can result in new vulnerabilities of the leukemia cells to drug treatment.

Website unit:https://gbiomed.kuleuven.be/english/research/50488876/LDMC/

Responsibilities

The candidate will lead a new project to explore the co-operation between ribosome defects and co-occurring oncogenic events in T-cell ALL. The project will use cell-based and mouse models, proteomics, expression analysis and metabolomics.

This work is part of a larger collaborative project involving Prof. Kim De Keermaecker (KU Leuven), Prof. Jan Cools (KU Leuven – VIB), Prof. Johan Maertens (UZ Leuven – KU Leuven), Prof. Heidi Segers (UZ Leuven – KU Leuven) and Prof. Nancy Boeckx (UZ Leuven –KU Leuven), in which additional oncogenes in ALL are studied. The successful applicant is expected to provide support to the coordination of this larger project and for supervising students working on different aspects of the project.

Profile

You obtained a PhD within the last 5 years or are close to obtaining a PhD in a relevant discipline
You have a strong publication record
You have a background in cancer biology
Experience in working with mouse models and mammalian cell cultures as well as with standard molecular biology techniques is a strict requirement (transfection, PCR,western blotting, immunoprecipitation, cloning,…).

Apart from being a true team player, the candidate is expected to exhibit a high degree of independence, to have a problem-solving attitude and have strong analytical and technical abilities in addition to excellent communication and presentation skills.
You are fluent in English, both written and spoken.

Offer

An exciting job in a stimulating and supportive international research environment at KU Leuven, an international top research institute.
Excellent training opportunities to broaden your technical and academic career skills.
1-year postdoctoral position with possibility of extension for another 3 years provided a positive evaluation. The successful candidate will also be encouraged and will get full support to obtain independent fellowships (Marie-Curie, EMBO, or National funding organizations).
Our lab is situated in Leuven, a charming and vibrant university city that is only a 20 minutes away from the city of Brussels, at the heart of Europe.

Interested?

For more information please contact Prof. dr. Kim De Keersmaecker, mail: kim.dekeersmaecker@kuleuven.be
You can apply for this job no later than October 31, 2018 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Please apply via recruiter’s website.

Favorite