Postdoctoral Research Associate – Developmental Neurobiology, Stem Cell, Cancer, Neuroscience
St. Jude Children’s Research Hospital
St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.
A postdoctoral position to study the molecular and cellular mechanism of brain development and cancer are available at the St. Jude Children’s Research Hospital in Memphis, TN, USA. The neocortex, the seat of complex behavior, cognition, and intellect, is tremendously expanded and folded in certain mammals including humans. However, little is known about the mechanisms underlying this neocortical expansion and folding (gyrencephaly). We have shown that Hedgehog signaling promotes gyrencephaly and generated the first transgenic murine model for gyrencephaly, where the small and smooth murine neocortex becomes large and folded one with anatomical and developmental hallmarks of gyrencephalic brains (Wang et al., Nature Neuroscience, 2016). We also use human cerebral organoids and a naturally gyrencephalic model organism, to extend our findings in murine models to naturally gyrencephalic species. Using these models, we identified several genes that may play key roles in expansion and folding of the neocortex. We seek candidates who will (1) study the function of these identified genes in neocortical expansion and folding or (2) investigate the development and function of expanded and folded cortical area in a mutant murine model at the cellular, anatomical, physiological, and behavioral levels.
Another research focus is the function of primary cilia and Hedgehog signaling in cancer. Primary cilia play critical roles in multiple signaling pathways and cell cycle progression. We have shown that primary cilia can either promote or prevent cancer depending on the initiating oncogenic mutation (Han et al., Nature Medicine 2009). Recently, we showed that Hedgehog signaling controls protein translation through an mTORC1/4EBP1-dependent pathway and mTORC1 can be targeted to treat medulloblastoma, the most common pediatric brain cancer (Wu et al., Dev Cell, 2017). Currently, we are investigating the molecular and cellular mechanism of ciliary function in medulloblastoma and the function of translational targets of Hedgehog signaling in medulloblastoma.
We seek a highly motivated individual who has a strong background and interest in development, stem cell, neuroscience, or cancer. We are particularly interested in experts in in utero gene delivery and live-cell imaging. Qualified applicants should apply for job 39201 at https://bit.ly/2Il3k4w and send a summary of previous research, curriculum vitae, and contact information for three references.
Young-Goo Han, PhD
Developmental Neurobiology Department
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105
St. Jude Children’s Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, age, religion, disability, sexual orientation, gender identity, transgender status, veteran’s status or disabled veteran’s status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.