Post-doctoral fellowship positions in translational leukemia research

Post-doctoral fellowship positions in translational leukemia research

Lund University, Division of Clinical Genetics

Lund, Sweden

Post-doctoral fellowship positions in translational leukemia research at Lund University, Sweden.

Lund University, located in Southern Sweden, is Scandinavia's largest Institution for education and research in areas including technology, science, law, social sciences, economics, medicine, humanities, theology and performing arts. The University has around 40,000 students and 6,000 employees (1). The Division of Clinical Genetics at Lund University is a world-leading research environment in cancer research consisting of eight principal investigators working with leukemia and solid tumor research (2).

Based on a series of recent research breakthroughs published in high-impact journals and a prestigious grant from the Knut and Alice Wallenberg Foundation, we are expanding our research efforts in translational leukemia research. We now offer two post-doctoral fellows to join the research group of Professor Thoas Fioretos (3, 4). The research group focus is on understanding how leukemia arises and best can be treated by using a combination of translational high-resolution methods and functional studies. The research group collaborates closely with clinical departments at the university hospital to implement key findings in healthcare and has a strong track-record in generating innovations (5, 6). The positions provide excellent opportunities for continuous education, research seminars and participation in international conferences.

Description of positions

Two post-doctoral fellowships are available and they will work in close collaboration with senior scientists in the group:

1. The first candidate will join our team working with integrative sequencing of acute leukemia samples. In this project whole-exome sequencing (WES), RNA-sequencing, whole genome sequencing (WGS), and advanced bioformatics are used to identify disease-causing alterations in primary acute leukemia samples and to translate key findings into a clinical diagnostic setting at the national level. The team also works to develop methods for single-cell sequencing and to track clonal evolution following treatment of acute leukemia. Using integrative sequencing, the research group recently identified two new subgroups of pediatric acute lymphoblastic leukemia (Lilljebjörn et al., Nat Commun, 2016; Lilljebjörn & Fioretos, Blood 2017) and a new recurrent alteration in acute myeloid leukemia (Lazarevic et al., Blood 2017).

2. The second candidate will join our team working on functional modeling of acute leukemia and on target identification on leukemia stem cells. In this project, in vitro and in vivo models, advanced cell sorting, and single-cell sequencing are used to dissect mechanisms involved in leukemia development and to identify targets on leukemia stem cells that can be used for antibody-based therapies. The team recently identified the cell surface marker IL1RAP as a target for treatment on leukemia stem cells (Askmyr et al., Blood 2014; Ågerstam et al., PNAS 2015, Ågerstam et al., Blood 2016).

Qualifications

We are looking for highly motivated and enthusiastic researchers with strong interest in translational leukemia research with a recent PhD degree (not more than three years old at the last day of applying). Candidates who are currently finishing up their PhD thesis are also invited to apply. For the first position, previous hands-on experience in high-throughput sequencing methods, molecular genetic methods and bioinformatics analysis is advantageous. For the second position, previous hands-on experience from in vivo studies, flow cytometry and work with hematopoietic cells is advantageous.

Applicants are expected to have recent first author publications in internationally renowned peer-reviewed journals. Ability to work independently, as well as part of a team is essential. Excellent verbal and written communication skills in English are required for consideration.

How to apply

Interested candidates should provide: 1) a statement of interest on one separate page, 2) a curriculum vitae, 3) a list of publications, and 4) the contact information of three references.

Candidates interested for the first position should send the required information to Drs Henrik Lilljebjörn (Henrik.Lilljebjorn@med.lu.se) and Christina Orsmark-Pietras (Christina Orsmark-Pietras@med.lu.se).

Candidates interested for the second position should send the required information to Drs Helena Ågerstam (Helena.Agerstam@med.lu.se) and Carl Sandén (Carl.Sanden@med.lu.se).

Last day of application is November 23, 2018

References and links

1. www.lunduniversity.lu.se
2. http://research.med.lu.se/clinical-genetics
3. www.researchgate.net/profile/Thoas_Fioretos
4. www.research.med.lu.se/thoas-fioretos
5. www.qlucore.com
6. www.cantargia.com

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Post-doctoral fellowship positions in translational leukemia research