Post-Doctoral Position in Molecular and Cellular Biology Designing, Constructing and Applying Fluorescence-based Cellular Biosensors for Human Microphysiology Systems of the Liver and Pancreatic Islets.

Post-Doctoral Position in Molecular and Cellular Biology Designing, Constructing and Applying Fluorescence-based Cellular Biosensors for Human Microphysiology Systems of the Liver and Pancreatic Islets.

University of Pittsburgh Drug Discovery Institute (UPDDI)

Pittsburgh, United States

In the laboratory of D. Lansing Taylor, Ph.D., Director, University of Pittsburgh Drug Discovery Institute (UPDDI) Distinguished Professor and Allegheny Foundation Professor of Computational and Systems Biology

Start Date: Fall 2018
Funding from NIH-NCATS, the EPA, and NIH-NIDDK, NIH-CTSA

Experience and Training
• Ph.D in molecular biology, biochemistry, cell biology or related field
• Experience in designing and constructing fluorescence-based biosensors using fluorescent proteins
• Experience with lentiviral transduction methods for delivering biosensor constructs to cells
• Experience with CRISPR/Cas 9 a plus
• Experience in using automated imaging systems a plus
• Experience with primary human cells and iPSCs a plus.

Position Responsibilities
• Design, construct and apply fluorescence-based biosensors to report on pathophysiology in a human, 4 cell-type, liver disease MPS including non-alcoholic fatty liver disease and type 2 diabetes over one month based on primary human cells and iPSC-derived cells
• Collaborate with colleagues to integrate the human liver MPS with other organ MPS including pancreatic islets, white adipose tissue, intestine
• Plan and execute experiments, analyze and present results in presentations and publications
• Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt

Applicants are invited to send their CV, and names of two references (or reference letters) to: cmg72@pitt.edu or mail to:
Christine M Grabowski
Administrator
Drug Discovery Institute
University of Pittsburgh School of Medicine
W955 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15261, USA

The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer

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Position

Post-Doctoral Position in Molecular and Cellular Biology Designing, Constructing and Applying Fluorescence-based Cellular Biosensors for Human Microphysiology Systems of the Liver and Pancreatic Islets.