Post-Doctoral Biomedical Engineer Position in Human Liver Microphysiology Systems (MPS)
In the laboratory of D. Lansing Taylor, Ph.D., Director, University of Pittsburgh Drug Discovery Institute (UPDDI), Distinguished Professor and Allegheny Foundation Professor of Computational and Systems Biology
Start Date: Fall 2018
Funding from NIH-NCATS, the EPA, and NIH-NIDDK, NIH-CTSA
Experience and Training
• Ph.D in biophysics, biomedical engineering, or related field
• Experience in microfluidics
• Experience in cell biology/cell cultures
• Experience in high content imaging or confocal microscopy
• Experience with iPSCs a plus.
• Extend the development of a human, 4 cell-type, microphysiology liver model using an all glass microfluidic device and oxygen sensing techniques to construct a vascularized, zonated liver acinus.
• Characterize the structure and functions of a liver disease model MPS for over a month (options include hepatocarcinoma, metastatic breast or melanoma cancers, non-alcoholic fatty liver disease and Type 2 Diabetes) using a variety of readouts including imaging fluorescence-based biosensors, biochemistry and mass spectrometry.
• Plan and execute experiments, analyze and present results in presentations and publications
• Collaborate with the liver microphysiology systems team and clinician-scientists at Pitt
UPDDI is searching for a Postdoctoral Microphysiology Biomedical Engineer for the development and analysis of human, 3D cellular models of organs and disease based on microfluidic devices. Expertise in microfluidics and experimental use of fluorescence imaging microscopy of cellular systems is required. Experience with 3D biological models preferred. This is an excellent opportunity to get involved in a series of high profile collaborations in engineering microfluidic organ models for disease modeling and toxicology testing.
Applicants are invited to send their CV, and names of two references (or reference letters) to: firstname.lastname@example.org or mail to:
Christine M Grabowski
Drug Discovery Institute
University of Pittsburgh School of Medicine
W955 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15261, USA
The University of Pittsburgh is an Affirmative Action, Equal Opportunity Employer