Postdoctoral Scientist in Leukaemia Biology

Nuffield Division of Clinical Laboratory Sciences, University of Oxford

Oxford, United Kingdom

Salary: Grade 7: £31,604 - £38,833 p.a.

We seek a driven, highly motivated and talented Postdoctoral Scientist to join the research group of Professor Paresh Vyas at the MRC Weatherall Institute of Molecular Medicine (WIMM) to work the detailed mechanisms of how a mutated transcription factor GATA1 causes leukaemia in children. The post is available fixed-term until 31 July 2019 funded by the charity Bloodwise and will involve collaborations with multiple groups in WIMM and University of Oxford.

Children with Downs Syndrome have a 500-fold risk of developing an aggressive acute leukaemia. All cases of this leukaemia have acquired mutations in the transcription factor GATA1 as the first event that leads to a preleukaemic state. We have identified the key blood progenitor populations where mutant GATA1 alters haemopoiesis. The aim of this project is to dissect the detailed mechanisms of how mutant GATA1 creates the preleukaemic state. Insights gained will provide general principles in leukaemia biology. The Vyas lab has a long-standing interest in the biology of normal and leukaemic stem cells. There will be close collaboration with the Porcher lab (developmental haemopoiesis), Roberts lab (fetal haemopoiesis), Milne and Higgs labs (epigenetics), Nerlov and Mead labs (haemopoiesis) Fulga lab (synthetic biology) and the WIMM Bioinformatics groups, NGS core, Genome Engineering core, FACS facility and Single Cell facility.

You will hold a PhD in a relevant area, with experience of CRISPR-Cas9 genome engineering, FACS, haematopoietic stem/progenitor cell cultures, RNA-Seq, ATAC-Seq and ChiP-Seq. Extensive bioinformatics expertise, including coding in R and a strong publication record are essential, as well as the ability to work independently as well as part of a team.

Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for this position is 12.00 noon on Wednesday 22 August 2018. Interviews will be held on Monday 10 September 2018.

Please apply via recruiter’s website.

Quote Reference: University of Oxford-itox_ac-136070