Postdoc in DNA Damage Response and Innate Immunity

Postdoc in DNA Damage Response and Innate Immunity

The Laboratory for Molecular Infection Medicine Sweden (MIMS)

Umeå, Sweden

We are looking for a postdoc with training in signal transduction to join our team in the Laboratory for Molecular Infection Medicine Sweden (MIMS)(http://www.mims.umu.se/groups/nelson-gekara.html). The postdoctoral fellowship initially for two years subject to extension starts as soon as can be arranged.

Project description
We are interested in understanding the mechanisms that govern the regulation of the DNA damage response and Innate immune signaling pathways and how the breakdown of such regulation influences the outcome of infections, inflammatory diseases and genome instability – associated disorders (Panda S, Nilsson JA, Gekara NO. Immunity. 2015 Oct 20;43(4):647-59; Härtlova A, et al., Immunity. 2015 Feb 17;42(2):332-43 and Erttmann SF, et al., Immunity. 2016 Jul 19;45(1):106-18). We have identified new regulatory molecules involved in the regulation of the DNA damage response and the immune system. The goal of this project is to investigate their role and mechanisms in health and disease.

Qualifications
You have or are about to have a Ph.D in cell/molecular biology, biochemistry, immunology or related fields. You are proficient in spoken and written English and have good communication skills.

Desirable qualifications
Interest in DNA damage signaling and/or immunology is a merit. Expertise in cell signaling, proficiency in cell culture, transfections, lentiviral /retroviral approaches for gene manipulation, immunoprecipitations, western blotting, ELISA, RT-qPCR and other cell/molecular biology techniques is required.

You apply directly to Nelson O. Gekara Email: nelson.gekara@umu.se, Tel: +46 90-785 08 20.

The application shall include:
o A CV with information on education a list of previous and current employments
o A list of publications
o A personal letter containing research experience and interests, motivation for applying.
o Contact details of three references.
Documents should be sent electronically as one file in a PDF format latest by 31 August 2018.
We look forward to receiving your application!

More about us
Our lab (http://www.mims.umu.se/groups/nelson-gekara.html) is part of the Laboratory for Molecular Infection Medicine Sweden MIMS (www.mims.umu.se). MIMS is the Swedish node in the Nordic EMBL Partnership for Molecular Medicine (http://www.embl.de/research/partnerships/remote/nordic/index.html
and www.nordicemblpartnership.org) and hosted with the multidisciplinary Umeå Centre for Microbial Research (UCMR, www.ucmr.umu.se).

About Umeå University
Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. More than 4300 employees and 31500 students have already chosen Umeå University. We welcome your application!

Umeå University offers exciting research opportunities in an excellent environment. The lab is located within the cross-disciplinary Chemical Biological Centre (video) (www.kbc.umu.se/english/) at Umeå University and provides excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. Facilities include Protein Expertise Platform, X-ray, Proteomics, NMR (850-400 MHz), Cryo-EM and Biochemical Imaging Centre (confocal, FLIM, spinning disk). The recent breakthrough researches from Umeå include deciphering the molecular mechanisms of the bacterial CRISPR-Cas9 system and repurposing it into a tool for genome editing….

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Position

Postdoc in DNA Damage Response and Innate Immunity