The Translational GlycOmics Program for Career Development in Glycoscience 1K12HL141954-01
Translational medicine fosters cross-functional collaborations between researchers and clinicians to facilitate new and precision-driven treatments for individualized therapy. While scientists and clinicians successfully applied this approach to four fundamental building blocks of life (nucleic acids, lipids, proteins and carbohydrates), the science of glycans (carbohydrates) has received the least attention. The diverse functions of glycans contribute to the structural integrity of biomolecules, extracellular matrix formation, signal transduction, protein folding, information exchange between cells, and host-pathogen interactions. Despite their functional diversity and specificity, carbohydrates are commonly associated with weight gain and diabetes while their major contributions to health and disease remain vastly understudied. Furthermore, the use and modulation of glycans has been largely unexplored in therapeutic strategies. There is an urgent need to support and educate glycoscientists concomitantly with the biology of human health and disease, thus enabling clinicians and glycoscientists to recognize medical needs and therapeutic opportunities.
To meet these needs, the National Heart, Lung, and Blood Institute (NHLBI) for the first time has offered a K12 Career Development Program in translational glycosciences titled “National Career Development Consortium for Excellence in Glycosciences.” One of the four national sites is the Translational GlycOmics Program (Translational GlycO Program), linking unique and diverse glycoscience expertise with research facilities, major teaching hospitals, blood banking and pharmaceutical education. Candidates must have U.S. citizenship, or U.S. permanent residency status at the time of appointment.
Candidates must have the appropriate doctoral degree (MD, MD/PhD, PhD or equivalent) and commit to at least 2 years of training. Eligibility includes post-doctoral fellows that have completed at least 2 years of research training or have gained exceptional research qualifications during their graduate training, physicians who have completed residencies or fellowships in clinical specialties, and early stage faculty members. Scholars will receive a salary commensurate with the Scholar’s qualifications and experience, and fringe benefits. Scholars will be selected on a competitive basis through a national search.
The Translational GlycOmics Program (Translational GlycO Program) is a multi-institution, multi-state program located at The Blood Research Institute and the Center for Translational Glycomics, BloodCenter of Wisconsin (BCW), in association with the Medical College of Wisconsin (MCW), Roswell Park Comprehensive Cancer Center (Roswell), and Virginia Commonwealth University (VCU). All institutions of the Translational GlycO Program are Equal Opportunity/Affirmative Action Employers M/F/D/V/SO
1. Applicants who have been or are currently PI on other federally mentored carrier awards (K series awards) or other federal mentored carrier awards.
2. Applicants who are currently PI on a federal grant (R01 and P01) or are PIs of a subproject on a federal program project (P01) and center grants (P50).
3. Applications who are not U.S. citizens or who do not have U.S. permanent residency status at the proposed starting dates.
Interested candidates are required to submit:
1. A completed application form, complete full Curriculum Vitae
2. Cover letter stating the desired location for Translational GlycO (BCW, MCW, Roswell, or VCU)
3. A 1 – 2 page personal statement summarizing A) past accomplishments; B) area of intended research; C) future career goals and timeline; D) justification on how K12 training correlates with career goals; and E) past and future interest in the field of glycosciences.
4. 3 letters of recommendations to independently reach the K12 program admin. See website for details
1. Center for Translational Glycomics, Blood Research Institute, Milwaukee, WI
Karin Hoffmeister, MD, Program Director, Director of the Translational Glycomics Center, Senior Investigator, Blood Research Institute, Professor of Biochemistry, Medical College of Wisconsin; Associate Professor of Pediatrics, Harvard Medical School
Peter J. Newman, PhD, Walter Schroeder Investigator and Associate Director of the Blood Research Institute, Professor of Pharmacology and Cell Biology, Medical College of Wisconsin, and Associate Director of the Medical College of Wisconsin Cardiovascular Research Center
Thomas Abshire, MD, Senior Vice President, Medical Sciences Institute (MSI), Section Chief of Benign Hematology at Medical College of Wisconsin, and Senior Investigator, Blood Research Investigator; Professor of Pediatrics, Medical College of Wisconsin and Clinical and Translational Science Institute (CTSI) of Southeastern Wisconsin
Hartmut Weiler, PhD, Senior Investigator and Ziegler Family Chair in Research, Blood Research Institute, Associate Professor of Physiology, Medical College of Wisconsin, Director of the Transgenic Core Facility, Blood Research Institute
Hervé Falet, PhD, Investigator, Blood Research Institute and Assistant Professor of Cell Biology, Medical College of Wisconsin
Sridhar Rao, MD, PhD, Associate Investigator, Blood Research Institute, Assistant Professor of Pediatrics and Cell Biology, Medical College of Wisconsin; Pediatric Bone Marrow Transplant Specialist
Greg Denomme, PhD/FCSMLS, Senior Director, Immunohematology and Innovation, Senior Investigator, Blood Research Institute; Director BloodCenter of Wisconsin Immunohematology Reference Laboratory and patient red cell genotyping
2. Medical College of Wisconsin, Milwaukee, WI
Nancy M. Dahms, PhD, Associate Program Director, Professor of Biochemistry, Medical College of Wisconsin
John A. Corbett, PhD, Professor and Chair of Biochemistry, Medical College of Wisconsin
William J. Rhead, MD, PhD, Professor of Pediatrics and Pathology, Medical College of Wisconsin, Pediatrician and Clinical and Biochemical Geneticist
Rebekah Gundry, PhD, Associate Professor of Biochemistry, Director Center for Biomedical Mass Spectrometry Research, Medical College of Wisconsin
Matthew Scaglione, PhD, Assistant Professor of Biochemistry, Medical College of Wisconsin
3 Roswell Park Comprehensive Cancer Center, Buffalo NY
Joseph T.Y. Lau, PhD, Associate Program Director, Distinguished Research Professor of Cell and Molecular Biology at the Roswell Park Division of State University of New York, Distinguished Member in the Department of Molecular and Cellular Biology and the Tumor Immunology and Immunotherapeutics Program at Roswell Park Comprehensive Cancer Center
Sriram Neelamegham, PhD, Professor of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo Clinical and Translational Research Center, Steering Committee of a NY State Stem Cell Training grant (NYSTEM)
Brahm H. Segal MD, Professor of Medicine and Vice Chair of Faculty Development, University at Buffalo Jacobs School of Medicine and Biomedical Sciences and Chief of Infectious Diseases, Member, Department of Immunology, and Director of Faculty Development, at Roswell Park Comprehensive Cancer Center, Chief of Infectious Diseases
Philip McCarthy, MD, Professor of Oncology & Internal Medicine and staff physician and Chief of the Blood and Marrow Transplantation (BMT) Program at Roswell Park Comprehensive Cancer Center
Kelvin Lee, MD, Jacobs Family Chair of the Department of Immunology, co-Leader of the Cancer Center’s Tumor Immunology and Immunotherapy Program, Professor of Medicine at Roswell Park Comprehensive Cancer Center
4. Virginia Commonwealth University, Richmond, VA
Umesh Desai, PhD, Associate Program Director, Professor of Medicinal Chemistry, School of Pharmacy, and Director, Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University
Bhaumik Patel, MD, Associate Professor of Medicine in the Division of Hematology and Oncology, McGuire VA Medical Center, Richmond and the VCU Health System/Massey Cancer Center, Virginia Commonwealth University
Krishna Rajarathnam, PhD, Professor of Biochemistry, University of Texas Medical Branch (UTMB), Galveston, TX
Kuberan Balagurunathan, PhD, Professor of Medicinal Chemistry, University of Utah
Adam Hawkridge, PhD, Assistant Professor, School of Pharmacy at Virginia Commonwealth University