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Postdoctoral Fellow in Stem Cell Biology and Pharmacogenomics

Northwestern University Feinberg School of Medicine, Chicago

Chicago, United States

A postdoctoral position is available in the laboratory of Dr. Paul Burridge in the Department of Pharmacology and the Center for Pharmacogenomics at Northwestern University Feinberg School of Medicine, Chicago, IL.

Successful candidates will be involved in human induced pluripotent stem cell studies to interrogate how the genome can be used to predict drug efficacy, minimize toxicity, and discover new drugs.

Projects combine patient recruitment, WGS, hiPSC models, RNA-seq, differential expression quantitative trait loci (deQTL) mapping, SNP validation, CRISPR/Cas9-mediated genome editing, and high-throughput drug discovery.

Major projects available include: 1, Genomics and hiPSC models of chemotherapy-induced toxicity. 2, hiPSC models of breast cancer progression and acquisition of resistance. 3, Genomics of heart failure and cardiomyopathy drug efficacy 4, Cardiac regenerative medicine including direct reprogramming.

Qualifications: Recent (within the last year) or upcoming PhD or PharmD degree and a strong record of peer-reviewed publications, including first-author, is essential.

Desirable expertise includes: hiPSC differentiation and/or direct reprogramming methodologies and disease modeling (primarily cardiac, also skeletal muscle, endothelial, fibroblast, blood, hepatocyte, renal, neural, cancer cell types, breast epithelial); experience in pharmacogenomics and bioinformatics using next-generation sequencing data types (WGS and RNA-seq); chemotherapy drug response/toxicity mechanisms and GWAS; high-throughput biology and drug screening.

Good verbal and written communication skills in English are essential. The successful candidate will join a dynamic research environment in the Department of Pharmacology, which offers both basic science and clinical translational opportunities to explore fundamental questions in pharmacogenomics. More details can be found here: http://labs.feinberg.northwestern.edu/burridge/

Salary will be according to NIH (NRSA) Scale and commensurate with experience.

Please send a CV (including publications), a cover letter containing a brief description of research experience and interests, and a list of 2-3 references to: paul.burridge@northwestern.edu

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Postdoctoral Fellow in Stem Cell Biology and Pharmacogenomics