A Postdoctoral fellow position is open in the laboratory of Dr. John P. Cooke, MD, PhD in the Center for Cardiovascular Regeneration (CCR) at the Houston Methodist Research Institute. Preferred candidates will have research background in cellular and molecular biology, specifically in mammalian cells. Preferred candidates will possess an interest in utilizing modern epigenetic techniques to explore the mechanisms by which innate immune signaling increases DNA accessibility, including ChIP-seq, RNA-seq, and single-cell analysis.
Dr. Cooke’s lab was the first to recognize the importance of innate immune activation in generating induced pluripotent stem cells (iPSCs). This work revealed that innate immune signaling causes global changes in epigenetic modifiers to facilitate reprogramming (Lee et al, Cell 2012). Innate immune signaling alters the balance of epigenetic modifiers to favor an open chromatin configuration so as to facilitate nuclear reprogramming. In addition, his lab discovered that innate immune activation is also critical in trans-differentiation, which is the direct reprogramming of one somatic cell to another of a different lineage. They observed that trans-differentiation is abrogated when innate immune signaling is disrupted via changes in epigenetic modifiers.
The Center for Cardiovascular Regeneration focuses on the discovery of new insights into the biology of cardiac and vascular repair. We bridge Houston Methodist's clinical expertise in managing cardiovascular disease with our translational research strengths in nanotechnology, imaging, systems medicine and genetics. The center discovers and develops new mechanisms and methods for cardiovascular repair and regeneration based on fundamental insights into the determinants of cardiovascular plasticity, reprogramming and aging. The center enjoys an interactive and collaborative environment ideal for scientific discovery. We believe and always emphasize that effective teams are an intermediate goal towards performing good science and sustainable results. Based on this concept, we offer multi-disciplinary training opportunities, including a weekly seminar series, journal clubs, and other career-development activities, such as grant writing.
Performs basic research duties under the supervision/direction of a Physician (Principal Investigator).
Apply at: www.houstonmethodistcareers.org…