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PhD Student – Structural and functional analysis of hepatic endothelial vs. hepatocyte heterogeneity at the single cell level

German Cancer Research Center (DKFZ).

Heidelberg, Germany

The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The Division of Vascular Oncology and Metastasis is seeking a

PhD Student
Structural and functional analysis of hepatic endothelial vs. hepatocyte heterogeneity at the single cell level

(Ref-No. 073/2018)

Endothelial cells line the inside of all blood vessels forming a structurally and functionally heterogeneous cell population. The heterogeneity of endothelial cells in different vascular beds has long been recognized. Yet, the association of organotypic heterogeneity signatures to cellular function is still in its infancy (Augustin & Koh, Science, 2017). Moreover, the recently emerging concepts of angiocrine signaling have stressed even more urgently the need to dissect in detail endothelial transcriptomic signatures in order to identify critical molecular determinants of angiocrine signaling (Rafii et al., Nature, 2016). Building on substantial expertise in the field of hepatic endothelial structure and function, this joint DKFZ-Weizmann Institute PhD project is aimed at dissecting hepatic endothelial vs. hepatocyte heterogeneity at single cell resolution in order to generate a structure-function angioarchitectural map, which will then be traced following genetic manipulation and/or pathophysiologic liver challenge. The two mentoring PIs (Prof. Hellmut Augustin [DKFZ Heidelberg, Germany] and Prof. Karina Yaniv [Weizmann Institute, Israel]) will towards this end synergistically exploit their expertise and laboratory technology in mouse and zebrafish vascular biology. The project is expected to yield fundamental insight into the mechanisms and consequences of endothelial heterogeneity with pathophysiological implications for the fields of hepatology and cancer biology.

This successful candidate will be part of the German-Israeli Helmholtz Research School in Cancer Biology, a joint PhD training initiative of the German Cancer Research Center in Heidelberg and the Weizmann Institute of Science in Rehovot, Israel. The PhD project will be primarily conducted in the laboratory of Prof. Hellmut Augustin at the German Cancer Research Center in collaboration with Prof. Karina Yaniv at the Weizmann Institute of Science. The successful candidate will therefore spend 6-9 months of the PhD working at the Weizmann Institute in Rehovot, Israel.

For further information about the Research School, please visit the website: https://www.dkfz.de/en/phd-program/GIHRS.html

Please submit the following documents in a single PDF file using the online link to apply for this position:

  • Cover letter
  • CV, including the names and contact details of two scientists who are willing to provide a letter of recommendation for your application.
  • Bachelor and master (or equivalent) certificates and transcripts

Your profile:
Motivation, dedication, talent and unconditional commitment to ambitious goals for a high end PhD project will be the primary selection criteria. Other than that, we are looking for a candidate who integrates well in a cosmopolitan laboratory with very different characters that is united by the common goal to pursue highly original cutting-edge vascular and tumor biology research. Experience in cell and molecular biology techniques is a must. Experience in bioinformatics techniques is beneficial, but not mandatory. Applicants should hold the equivalent of a master's degree.

The position is initially a 3-year position with the possibility to extend for a 4th year.

For further information please contact Prof. Dr. Hellmut Augustin, phone +49 6221 42-1500.

The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (www.dkfz.de/jobs).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.

Please apply via recruiter’s website.

Quote Reference: 073/2018