Howard Hughes Medical Institute (HHMI) is a science philanthropy whose mission is to advance biomedical research and science education for the benefit of humanity. We empower exceptional scientists and students to pursue fundamental questions about living systems, and work to share scientific discoveries with researchers, students, and science-curious individuals around the world. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S. Visit hhmi.org/careers to learn more about working at HHMI.
We are looking for a highly-motivated individual to join the laboratory of Dr. David Pellman at HHMI, the Broad Institute, and the single-cell genome center at Dana-Farber Cancer Institute.
The successful applicant will be responsible for analyzing single-cell whole-genome and whole-transcriptome sequencing data, and for interpreting, integrating, and relating transcriptional/genetic information to experimental data from live-cell imaging. The candidate should have a strong computational/analytical background, demonstrated knowledge of research methods, be able to adapt quickly, and be part of a multi-disciplinary team. The position will focus on a new avenue of research using genomics as a tool for experimental biology, studying mechanisms that drive rapid genome evolution.
- Work closely with computational and experimental colleagues to understand various methods for detecting/analyzing de novo mutations and gene expression changes at single cell level.
- Work alongside informatics colleagues to clean and analyze newly generated data and public datasets.
- Create pipelines using existing analysis tools to process data in an automated and efficient fashion; Application of these approaches to cancer genome analyses.
- Responsible for documentation and error reporting for existing tools.
- Ensure data quality control is constantly and consistently applied to incoming data sets.
- Create reports of data quality and communicate these to computational staff.
- B.S. required in mathematics, statistics, physics, engineering, computer science, bioinformatics or other fields with quantitative knowledge. Neuroscience or psychology graduates with considerable computational experience will also be considered. Applicants with advanced degrees are also welcome to apply.
- Strong initiative and ability to take ownership of assigned tasks and projects.
- Practical experience with Linux environments, proficient in a least one programming language (Java, C, Python), and one scripting language (e.g., MATLAB, R); interest in (or experience with) cloud computing a plus.
- Solid knowledge of basic statistics and statistical methods.
- Knowledge of genetic analysis and tools is preferred but not required.
- Familiarity with, or interest in, studying cancer genetics and cell biology.
- Demonstrated attention to detail and analytical skills.
- Ability to work effectively in a multidisciplinary team environment.
- Excellent communication and interpersonal skills.
- Excellent written and oral presentation skills.