Charité - University Medicine Berlin

Wissenschaftliche*r Mitarbeiter*in (Postdoc)

Charité - Universitätsmedizin Berlin

Berlin, Germany

The Charité – Universitätsmedizin Berlin is a joint medical faculty, which serves both Freie Universität Berlin and Humboldt Universität zu Berlin. As one of the largest university hospitals in Europe with an important history, it plays a leading role in research, teaching and clinical care. The Charité university hospital has also made a name for itself as a modern business with certifications in the medical, clinical and management fields.

*Wissenschaftliche*r Mitarbeiter*in (Postdoc)*
Field of application: Molekulares Krebsforschungszentrum
Campus: Charité Campus Virchow-Klinikum

An der Charité ist im neu geförderten systemmedizinischen e:Med-Forschungsnetzwerk „SeneSys“ (Krebsforschung) unter Leitung von Prof. Clemens Schmitt ab Januar 2020 folgende Position zu besetzen: Wissenschaftliche*r Mitarbeiter*in (Postdoc). Ziel des vom Bundesministerium für Bildung und Forschung (BMBF) im Rahmen des systemmedizinischen „e:Med“-Programms neu etablierten Konsortiums „SeneSys“ ist die experimentelle Ermittlung und mathematisch Modellierung von Therapieeffekten, v. a. des Therapie-induzierten Seneszenz-Zellteilungsstopps, bei Lymphomerkrankungen, um daraus neuartige Behandlungsansätze abzuleiten. Hierzu kooperieren fünf vorwiegend Berlin-basierte Arbeitsgruppen aus unterschiedlichen Forschungsdisziplinen und verschiedenen Einrichtungen unter federführender Leitung der Charité (Koordinator: Prof. Clemens Schmitt) miteinander.

Your area of responsibility
Multi-omics cross-species computational analyses in cancer research
We are interested in genetic programs and defects therein, which impact on tumor development and sensitivity to anticancer therapies, in particular cellular senescence, apoptosis and autophagy. We utilize transgenic mouse lymphoma (and other cancer) models with and without defined genetic lesions to dissect molecular mechanisms and to explore drug responsiveness in vivo by multiple omics techniques (genomics, transcriptomics, proteomics and metabolomcis) in a clinical trial-like format. This strategy is embedded in functional in vitro and in vivo investigations of primary human tumor material, especially lymphomas, in short-term culture and as patient-derived xenografts. Specific experimental approaches focus on (epi-)genetics, signaling, metabolism, stemness, plasticity and immunogenicity. Our central aim is to understand the role of altered cellular states in cancer biology and clinical presentation, and to convert molecular vulnerabilities identified in these test platforms into conceptually novel anticancer therapies. Computational biology, data mining and integrative cross-species analyses of datasets from various sources are at the heart of our activities. For information in greater detail please see, for example, publications from our lab such as Milanovic-M et al., Nature 2018, Yu-Y et al., Cancer Cell 2018, Jing-D et al., Blood 2017 or Dörr-JR et al., Nature 2013, and recent review articles by Milanovic-M et al. (Trends Cell Biol 2019) or Lee-S and Schmitt-CA (Nat Cell Biol 2019). Our study group is co-affiliated with the Department of Hematology, Oncology and Tumor Immunology at the Charité – University Medical Center (Humboldt University and Free University) and the Max-Delbrück-Center for Molecular Medicine (MDC) in Berlin.

Your profile
Join our highly motivated team if you are interested in systems medicine-driven approaches and novel strategies to dissect treatment- and outcome-relevant signaling modules and cell states in cancer. You hold a Ph.D. or equivalent, and you are familiar with all basic techniques in molecular biology, biochemistry and histology (i.e. cloning, analyses of proteins and DNA/RNA, cell culture, and immunohistochemistry). Your prime expertise is the computational analysis of large omics-derived datasets, potentially also mathematical modeling approaches. Lab communication is in English.

Ref. no.: DM.22.20

Start: from now on

Length of employment: until the date of 31.08.2022

Working time: 39 (hrs./week)

Pay scale: E13 to collective agreement TVöD VKA – K

Employees are grouped into pay scales according to their qualifications and personal requirements. You can find our collective bargaining agreements (Tarifverträge) here:
www.charite.de/en/careers/

For further information, please contact:
Angelika Borkowski
angelika.borkowski@charite.de
tel. no. 030-450 553896

Please send your application, quoting the above reference number, by email to
clemens.schmitt@charite.de

THE CHARITÉ – UNIVERSITÄTSMEDIZIN BERLIN
makes its human resources decisions based on suitability, competence and professional performance. At the same time, it strives to increase the percentage of women in management positions and takes this into consideration where candidates are equally qualified within the limits of what is legally possible. Applications from people with a migrant background are also explicitly welcome. Severely disabled applicants are given preferential consideration in the case of candidates with equal qualifications. A certificate of conduct, or an extended certificate of conduct, if applicable, must be submitted. Any travel expenses incurred cannot be reimbursed.

DATA PROTECTION NOTICE: Charité points out that personal data is stored and processed as part of the application process in different areas of Charité (e. g. faculty, staff committee, human resources department). Furthermore, the data may be transferred or processed within the group as well as in locations outside the group (e. g. authorities) to protect legitimate interests. By applying, you agree to our data protection regulations and terms of use, which you can find here: https://www.charite.de/en/service/data_protection/data_protection_during_the_recruitment_process/

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Position

Wissenschaftliche*r Mitarbeiter*in (Postdoc)