The gastroenterology department at National Children’s Research Center/CHI Crumlin is internationally recognised for management of children with gastrointestinal disorders. We believe that true excellence in clinical care must be underpinned by research and we have an established track record in translational research on inflammatory and infectious intestinal disorders over the past 20 years.
There is increasing recognition of the role of the intestinal microbiota in the pathophysiology of Crohn’s disease and ulcerative colitis yet precisely how the extremely diverse and complex microbial constituents are altered during disease and /or contribute to its pathogenesis is not clear. An emerging concept is that the functionality of core microbial constituents of the microbiota may be more important in disease pathogenesis than individual constituents. This project will examine the effect of reactive oxygen species on individual constituents of the faecal microflora.
The successful candidate will lead a three year project that aims to isolate, identify and characterise the effects of excess reactive oxygen species on individual core microbial constituents of intestinal samples from children with inflammatory bowel disease. The senior postdoctoral researcher (experience of at least one previous post-doctoral position) will be based at the In the Conway Institute University College Dublin and the NCRC/CHI Crumlin (Our Ladys Childrens Hospital). The candidate will interact closely with collaborators in clinical care, ROS biology and bacterial proteomics. The ideal candidate will have at least three years postdoctoral experience in microbiology. Preference will be given to candidates with experience in analysis of complex microbial populations, flow cytometry (especially involving bacteria) and phosphoproteomics. As the individual will lead the project, we are seeking a dynamic self-motivated and highly skilled researcher.