The laboratory of Andrei Chabes investigates how perturbations in the absolute and relative concentrations of dNTPs increase mutation rates by reducing the fidelity of DNA synthesis. Increased mutation rates and decreased genome stability due to misregulation in dNTP biosynthesis can result in genetic abnormalities in higher eukaryotes. Inadequate supply of dNTPs has been associated with several human disorders, in which the stability of nuclear and mitochondrial genomes is affected.
The Chabes laboratory has recently established several unique mouse models with imbalanced dNTP pools. The aim of this project is to investigate how imbalanced dNTPs pools affect nuclear and mitochondrial genome stability, cellular transformation and aging in these mouse models.
The laboratory of Andrei Chabes at the Department of Medical Biochemistry and Biophysics (www.medchem.umu.se) Umeå University, Sweden is offering two 2-year postdoctoral stipends to study the effects of imbalanced dNTP pools on DNA replication fidelity, cellular transformation and aging in mice. The study involves common methods in cell biology and biochemistry as well as analysis of genetically modified mice.
The candidates should hold a Ph.D. degree, or about to be awarded a Ph.D. degree, in cancer-, cell- or molecular biology. We are looking for candidates with experience in mouse models and with good knowledge of mouse genetics, physiology and anatomy. Very good oral and written communication skills in English are required. Emphasis will also be placed on personal qualities such as collaboration and communication skills as well as analytical capacity.
The application should be submitted as one single document in word- or pdf-format.
The application should include:
- A cover letter in which you describe your qualifications and motivation (max 1 page)
- CV and publication list
- Copies of diplomas
- Names and contact information of at least two references
For further information about the project and the stipend, please contact Prof. Andrei Chabes, Department of Medical Biochemistry and Biophysics at firstname.lastname@example.org. Webpage www.umu.se/en/staff/andrei-chabes/.
Your complete application, marked with reference number FS 2.1.6-2130-19, should be sent to email@example.com (state the reference number as subject), before 2019-12-20.
The Department of Medical Biochemistry and Biophysics is located within the Chemical Biological Centre (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the life/natural sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative, and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: www.umu.se/en/kbc.
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