Max Planck Institute of Immunobiology and Epigenetics (MPI-IE)

Two Postdoctoral Positions in mouse models to study epigenetics

Max Planck Institute of Immunobiology and Epigenetics (MPI-IE)

Freiburg, Germany

We are offering

Two Postdoctoral Positions in mouse models to study epigenetics

The Max Planck Institute of Immunobiology and Epigenetics is a world-class research institute based in Freiburg, Germany. The Epigenetic focus of the institute strives to understand how epigenetic mechanisms such as histone modifications and long non-coding RNAs guide cell responses to metabolic and other signals as well as drive cell fate decisions.

We are looking for two Postdoctoral scientists to work in the Department of Chromatin Regulation headed by Dr. Asifa Akhtar. The positions are available for an initial two-year appointment with the possibility of extension.

The Akhtar lab uses a combination of Drosophila and mouse models to investigate the mechanistic and physiological functions of the H4K16-specific histone acetyltransferase MOF/KAT8 and its associated protein complexes. The team of Asifa Akhtar has uncovered essential roles for MOF in cardiomyocyte function, mitochondrial metabolism (Chatterjee et al 2016, Cell) and in the capacity of kidney podocytes to respond to stress (Sheikh et al 2016, Oncogene). The lab recently showed that MOF also acetylates a wide range of non-histone targets. Lamin acetylation by MOF is essential for nuclear integrity in primary cells (Karoutas et al 2019, Nature Cell Biology), a mechanism whose physiological relevance will be important to explore in the future. Furthermore, the lab has reported the discovery of a new developmental syndrome originating from de novo mutations in MSL3, a gene encoding a member of the MSL complex (Basilicata et al 2018, Nature Genetics). In addition, the group is interested in understanding the epigenetic underpinnings of Koolen-de Vries syndrome, which is caused by heterozygous deletion or mutation in the gene encoding the NSL complex member KANSL1.

Your tasks:
We are looking for independent and motivated post-doctoral scientists interested in exploring cell type- and tissue-specific roles of MOF in the context of both NSL and MSL complexes. For this we seek applicants with a strong background in experimental work in mice. The recruited scientist will apply a combination of methodologies, including bulk and single-cell transcriptomics, chromatin immunoprecipitation, live-cell imaging, proteomics, metabolomics or other techniques, as appropriate.

Your qualifications:

  • Applicants should have an academic degree in life science plus a PhD in molecular biology, biochemistry, genetics, bioinformatics and/or high-resolution imaging
  • Prior experience working with mouse models is required
  • Previous experience in working on cardiac or neural development would be advantageous
  • Experience in working with primary cell culture would be an advantage
  • Candidates should have at least one first author publication
  • The ability to work in a team, communication skills and experience in the supervision of graduate students are an asset

We offer:
The MPIIE in Freiburg is a hub for epigenetics research located at the cross-roads of Southern Germany, Switzerland and France. The Institute offers a friendly, international and collaborative environment with English as its working language.

The institute is equipped with state-of-the-art infrastructure and service units, including transgenesis, deep-sequencing, metabolomics, proteomics, flow cytometry and imaging facilities are available.

Salary will be based on previous experience according TVöD guidelines.

Application deadline:
Have we sparked your interest? Please submit your complete application, including a statement of research interests and a CV via our online application portal at http://www.ie-freiburg.mpg.de until February 7th, 2020. At the same time, please ask three of your referees to send recommendation letters to akhtarassistant@ie-freiburg.mpg.de.

Max Planck Institute of Immunobiology and Epigenetics
Stübweg 51
79108 Freiburg

Our Institute investigates the molecular basis of the immune response and other topics of the developmental biology, such as the origin and differentiation of the immune cells as well as the development of vertebrate embryo. Another main focus of the Institute is Epigenetics. This area deals with inheritable traits, which are not caused by changes in the DNA sequence.

Handicapped applicants with equal qualifications will be given preferential treatment. The Max Planck Society seeks to increase the number of women in areas, where they are underrepresented, and therefore explicitly encourages women to apply. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. A childcare facility is directly attached to the Institute.

If you would like to work in a dedicated team, please convince us now by sending us your complete application documents together with your salary expectations and your earliest possible date of joining the Institute.

Max Planck Institute
of Immunobiology and Epigenetics
Ms. Laule

Please apply via recruiter’s website.