A postdoctoral position in comparative single-cell functional genomics is available in the Cotney Lab. Our laboratory is applying functional genomics techniques at the single-cell level (ATAC-Seq, RNA-Seq, etc) to identify novel gene regulatory elements and gene expression programs in early mammalian craniofacial development. This NIH funded work seeks to understand the genetic basis of developmental disorders of the human face by integrating multiple types of functional genomics data at the single-cell level from mouse and human. See the Cotney Lab website (cotney.research.uchc.edu) and recent published work (Wilderman et al., Cell Reports, 2018) for more information about our group and our research
The ideal candidate would have a mixture of both experimental and computation experience including:
- General tissue culture techniques, including culturing of human and mouse cell lines, primary cells, embryonic stem cells and iPSCs.
- Chromatin immunoprecipitation
- Genome editing (CRISPR)
- Large scale enhancer screens
- Scripting languages such as Python or Perl
- Statistical packages such as R or Matlab
- Next generation sequencing and/or single-cell data analysis.
- Visualization of genomic data including IGV or UCSC Genome browser.
A postdoctoral position in stem cell models of 15q imprinting disorders is available in the Chamberlain Lab within the same department and institution. Our laboratory applies genome editing (CRISPR) and genomics technologies (RNA/ChIP-seq + others) to hESC/iPSC models of Angelman, Prader-Willi, and Dup15q syndromes to study chromatin dynamics, gene regulation, and disease mechanisms for these disorders. Our work is funded by the NIH and biotech/pharma with the ultimate goal of better understanding and identifying therapeutic approaches for these neurodevelopmental disorders.
The ideal candidate would have experience in:
- General tissue culture techniques, ideally including mouse or human ESCs or iPSCs.
- Neuronal differentiation of mouse and/or human iPSCs/ESCs
- Genome editing (CRISPR)
- General molecular biology and cloning
- Next generation sequencing data generation and analysis
How to Apply
About Our Organization
UConn Health is a vibrant, integrated academic medical center that is entering an era of unprecedented growth in all three areas of its mission: academics, research, and clinical care. Based in Farmington, Connecticut – a popular suburb of the state’s capitol of Hartford – UConn Health is home to the School of Medicine, School of Dental Medicine, John Dempsey Hospital, UConn Medical Group, UConn Health Partners, University Dentists and a thriving research enterprise including the Jackson Laboratory for Genomic Medicine and the UConn Technology Incubation Program. With approximately 5,000 employees, UConn Health is a major economic driver in the region, generating nearly $1 billion annually in gross state product. It is closely linked with the University of Connecticut’s main campus in Storrs through multiple, cross-campus academic projects.
UConn Health is an affirmative action employer, in addition to an EEO and M/F/V/PWD/PV employer.