Heidelberg University (Uni Heidelberg)

Two postdoctoral positions at the Institute of Human Genetics

University Hospital Heidelberg

Heidelberg, Germany

Two postdoctoral positions at the Institute of Human Genetics, University Hospital Heidelberg

Location: Institut of Human Genetics, INF 366, 69120 Heidelberg
Contract: 2 years with extension possibilities, earliest begin March 2020
Salary: Competitive, subject to skills and experience

The newly created Nephrogenetics unit headed by Matias Simons is looking for two enthusiastic postdocs to join our research group at the Institute of Human Genetics of the University Hospital Heidelberg. The positions will be funded by an ERC Consolidator Grant. The general interest of the lab is in the molecular mechanisms underlying hereditary kidney and metabolic diseases. Most of these diseases are caused by single-gene defects and thereby offer unique opportunities to decipher fundamental regulatory pathways of human physiology and to develop targeted diagnostic and therapeutic options. We are particularly interested in diseases affecting renal proximal tubules, a nephron segment specialized in protein and lipid endocytosis. Recent publications include Marchesin et al, Cell Rep in press; Bedin et al, J Clin Invest 2019; Goncalves et al, PloS Genetics 2018; Simons, JASN 2018; Rujano et al, J Exp Med 2017; Trepiccione et al, JASN 2016; Gleixner et al, Cell Rep 2014. We combine human genetics with several experimental approaches, including fly and mouse genetics, cell culture, microscopy and biochemistry.

We offer two exciting projects aimed at 1.) exploring the role of protein and lipid reabsorption and mitochondrial dysfunction in a fly model for diabetes and 2.) blocking proximal tubular protein reabsorption for renal protection in proteinuric mouse models. For both projects, we invite applications from individuals with a solid background in molecular cell biology. Prior experience with Drosophila and mouse, respectively, is an advantage but not a prerequisite. The projects will be carried out in a stimulating work environment with scientific collaborations within the institute, across the Heidelberg life science community (e.g. EMBL, DKFZ) and worldwide.

The successful applicants will have good communication and organisational skills and a PhD in a relevant area (or be in the final stages of completion). We also invite applications from research-oriented MDs. Candidates are expected to be highly motivated and to work independently with a strong work ethic. As we are an international lab, proficiency in English language is a requirement. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible and by Jan 31th, 2020 the latest to matias.simons@institutimagine.org.

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Two postdoctoral positions at the Institute of Human Genetics