Aarhus University (AU)

Two postdoc positions in endothelial cell biology

Aarhus University (AU)

Aarhus C, Denmark

The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for one or two postdoctoral positions in endothelial cell biology in The Laboratory for Endothelial Cell Biology and Inflammation as per 1 March 2020 or as soon as possible thereafter. The start date is flexible. The positions are fixed-term full-time positions for two years with a possibility for further extension.

The ideal applicant has to be highly motivated and interested to study endothelial cells biology in obesity, have good communication skills and be able to independently drive research projects.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work either in the brand new ‘Skou Building’ or similar as we are in the process of modernizing our old facilities. You can read more about the department here and about the faculty here.

About the research group
The Laboratory for Endothelial Cell Biology and Inflammation was recently established at the Department of Biomedicine at Aarhus University, with the aim to explore basic functions of endothelial cells in health and disease. We combine molecular biology approaches with the available state-of-the-art technical resources at the Department of Biomedicine. We are particularly interested in looking at the intersection of endothelial cell dysfunction and progression of obesity. Along these lines, the vacant projects will explore interactions of immune and the vasculature of adipose tissue, investigating their roles in the progression of obesity.

The Laboratory for Endothelial Cell Biology is led by assistant professor and Aarhus Institute for Advanced Studies (AIAS) fellow, Dr. Joanna Kalucka. We recently received a major 5-year grant for the project related to the open positions, ensuring ample project funding.

About the research project
Obesity is an increasingly challenging problem worldwide. During the expansion of adipose tissue, impaired vascular remodeling promotes hypoxia and inflammation resulting in increasing occurrence of obesity-related disorders. Therefore, malfunctional blood vessels have become clinically recognized as a life-threatening incidence for human health.

Dysfunctional endothelial cells may differ from healthy cells in e.g. immune-modulatory properties, and depending on the microenvironment, they might possess the ability to control the immune reaction and accelerate the progression of a disease. Given the emerging importance of understanding the heterogeneity of endothelial cells, by applying a multidisciplinary approach, this project aims to provide a characterization of endothelial cells heterogeneity in adipose tissue (in obese vs. lean patients) and to provide the answers on what kind of impact the microenvironment represented by the obese state has on the health and dysfunction of endothelial cells. The project will explore further characterization of endothelial cells using state-of-the-art techniques (including single cell RNA-seq, metabolomics, proteomics), in vivo and in vitro functional validation assays and mouse models.

Your competences

  • You have academic qualifications at PhD level and a solid background, preferably within one or more of the following areas: (endothelial) cell biology, immunology, or relevant.
  • Good knowledge and expertise in mammalian cell culture and/or animal models is required.
  • Experience with flow cytometry, bioinformatic analyses and single-cell technologies would be beneficial. Furthermore, we expect you to demonstrate a scientific track record.

As a person, you must be highly motivated and self-driven, proactive as well as critically-thinking, and to be able to lead your research project. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.

Questions about the position
If you have any questions about the position, please contact Dr. Joanna Kalucka, email joanna.kalucka@aias.au.dk.

Your place of work will be the Department of Biomedicine, Skou Building, Høegh-Guldbergs Gade 10, 8000 Aarhus C, Denmark.

We expect to conduct interviews January/February 2020.

Terms of employment
Application
Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • References/recommendations can be uploaded separately in the e-recruitment system
  • Template for applicant – postdoc must be completed and uploaded under ‘Extra documents’

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.

International applicant?
Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University’s website.

Aarhus University
Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

Deadline:
30 November 2019

Please apply via recruiter’s website.

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