The Department of Medical Biochemistry and Biophysics (Umeå University, Sweden) invites applicants for three post-doc fellowships for studies of DNA replication in the research group headed by Prof. Erik Johansson at Umeå University, Sweden. The focus of his research group has been to bring light to how DNA Polymerase epsilon participates in DNA replication, contributes to the high fidelity of DNA replication, and is involved in DNA repair. The lab uses structural biology, biochemistry and yeast genetics to elucidate the role and function of DNA polymerase epsilon.
For more information please visit the web-page: https://www.biostruct.umu.se/principal-investigators/erik-johansson/
The fellowships are for two years and are placed at the Department of Medical Biochemistry and Biophysics (https://www.umu.se/en/department-of-medical-biochemistry-and-biophysics/).
1. Recently the research group solved a structure of DNA polymerase epsilon harboring an Fe-S cluster in the catalytic domain (Nucleic Acids Res. 2019 47:5712-5722). However, the function of the Fe-S cluster is still elusive. This project is aimed to shed light on the function of the Fe-S cluster in DNA polymerase epsilon and whether it has a role during leading strand synthesis or DNA repair.
2. The reconstituted eukaryotic DNA replication system was recently set up in the research group. In this system we will study the events that occur when the replication fork meets a single-strand break, considered to be the most common lesion in the cell. The studies will involve structural studies, biochemical assays where purified proteins are added, and yeast genetics.
3. With the already mentioned reconstituted DNA replication system the fidelity of DNA replication will be studied in the context of the entire replication fork. Earlier studies have been limited to DNA polymerases filling a single-stranded gap or extending a primer.
Last day of application is December 5th, 2019. For information about how to apply follow this link: https://www.umu.se/en/research/groups/erik-johansson/open-positions_group-erik-johansson/ or use ‘Apply via Recruiter’ button.
What we offer
• An opportunity to live in the exciting northern part of Sweden;
• As a fellow we offer support that can help you relocate;
The Department of Medical Biochemistry and Biophysics is located within the Chemical Biological Centre (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the natural/life sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative, and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: www.umu.se/en/kbc.
Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programmes, world leading research, and excellent innovation and collaboration opportunities. More than 4 300 employees and 33 000 students have already chosen Umeå University. We welcome your application!