Evotec, France

Team leader in vivo phamacology/immunology & inflammation


Toulouse, France

General Summary :

  • Collaborate within a highly matrixed environment to advance preclinical drug development programs from target identification/validation through nomination of preclinical drug candidates.
  • Develop and utilize in vivo/ex vivo assay systems to demonstrate target engagement, establish PK/PD relationship, and assess therapeutic efficacy of lead compounds on inflammatory responses.

Missions and responsibilities :

  • Utilize in vivo models to assess therapeutic efficacy of lead compounds on inflammatory responses. This includes establishment of standard and bespoke in vivo/ex-vivo systems to allow PK/PD modeling, demonstrate in vivo target engagement and elucidate mechanisms of action.
  • Take leadership roles for assigned projects. Leads cross-functional teams in support of contract related deliverables. Ensure timely delivery of high quality data. Meet budget objectives.
  • Design, plan and supervise in vivo experiments.
  • Analyze, interpret and report study outcomes to project teams or clients.
  • Represents the in vivo pharmacology expertise as a member of multidisciplinary project teams.
  • Supports the business development team’s efforts to secure contract opportunities: Promotes immunology and inflammation services and translational models that will help grow customer base and client experience. Participates in preparing integrated drug discovery project proposals.
  • Maintain knowledge of scientific and competitive progresses within areas of expertise. Provide scientific input on new molecular targets and scientific due diligence. Present scientific work in conferences and congresses.
  • Train, mentor and supervise a team of assistant/associate scientists. Provide skill and career development opportunities to direct reports.
  • Collaborate with Institutional Animal Care and Use Committee to ensure compliance with national animal welfare regulations.
  • Contribute to continuous process improvement initiatives by supporting or integrating Lean project teams
  • Participate in maintaining a safe work environment for self and coworkers at all time

Knowledge, skills and abilities :

  • In vivo pharmacology background with experience in PK/PD modeling
  • Good understanding of the drug discovery process
  • Robust knowledge of biology targets, cellular and molecular pathways relevant to immunology and inflammation.
  • Thorough knowledge of animal models such as inflammatory bowel disease, lupus, skin fibrosis or rheumatoid arthritis. Hands-on experience with rodent models and ex-vivo analyses using immunoassays, flow cytometry, histology and/or immunohistochemistry techniques.
  • Strong supervisory skills
  • Excellent interpersonal skills, able to work in a multicultural, multidisciplinary and business-oriented environment
  • Effective verbal and written communication skills. * Fluent in English.
  • Rigorous, organized, creative and open-minded

Experience and education :

  • Degree or PhD level qualification in the field of relevance to immunology/inflammation and/or pharmacology.
  • Laboratory animal science diploma (level 1/FELASA A)
  • Mininum 2-3 years post-doc or industry experience

Please apply via recruiter’s website.