Astex Pharmaceuticals Limited

Sustaining Innovation Postdoctoral

Astex Pharmaceuticals

Cambridge, United Kingdom

Job Title: Sustaining Innovation Postdoctoral Research Associate
Project Title: Exploiting CRISPR tiling technology to identify functionally important regions of proteins

Job Type: 3 Year Fixed Term Contract, Full Time

Location: Cambridge, UK

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and BalversaTM partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.

The Astex Sustaining Innovation Postdoctoral research program has a track record of performing cutting-edge research and development and is a key element of our excellent scientific culture. During your SI Postdoc project you will be exposed to a multi-disciplinary pharma environment. You’ll benefit from our internal training seminars that will enhance your understanding of the drug discovery process. As part of your career development, you will have the opportunity to present your work within the company and at external meetings and you’ll be expected to publish your findings in high-impact journals.

As a member of the Translational Biology department, the successful candidate will establish and implement CRISPR tiling technologies, applying the technology to identify functionally important regions in proteins of interest. In this laboratory-based role, the successful candidate will apply the technology in order to identify regions of proteins critical for cell viability and acquired resistance to signal transduction inhibitors, furthering our understanding of the biology of cancer pathways. The candidate will subsequently validate these regions in a cellular context, using a range of cell and molecular biology techniques.

Candidate Requirements
• A PhD in a biological science and a strong publication record
• Direct experience and technical expertise in the setup, running and analysis of CRISPR functional genomic screens
• Demonstrable proficiency in a range of cell and molecular biology techniques including transient and stable genetic manipulation of cells and experience of applying these techniques to understanding fundamental biology
• The ability to contribute within highly multidisciplinary teams and work in a highly collaborative manner.

We offer excellent training and career development opportunities as well as competitive salary and benefits package.

Closing Date: 18th November 2019*
To apply please send your CV and a cover letter, quoting the job reference: SI-B002 to

For information on Astex Pharmaceuticals please visit:

and for information on Otsuka Pharmaceuticals please visit:


Apply with CV and Cover Letter

Must be a .doc, .docx, or .pdf file and no larger than 1MBMust be a .doc, .docx, or .pdf file and no larger than 1MB

Sustaining Innovation Postdoctoral