Merck & Co., Inc.

Sr. Scientist. Cell Engineering

Merck & Co., Inc.

Kenilworth, NJ, United States

Job Description

Our company’s Bioprocess is seeking a highly motivated and experienced Senior Scientist to advance the cell engineering capability for primary hematopoietic cells and immortalized cell lines. The Sr. Scientist will support biotherapeutics development pipeline and technology innovation in areas such as primary blood cell isolation, T cell activation and differentiation, and ex vivo gene editing. The successful candidate should have an in-depth understanding of immunology, T cell development, stem cell biology, molecular biology, and cell signaling. Candidate should have hands-on experience in these areas, including primary hematopoietic cell culture, Induced Pluripotent Stem Cells (iPSC) and/or Embryonic Stem (ES) cell culture, vector engineering, multi-color flow cytometry panel design and Western blotting analysis for Receptor Tyrosine Kinase (RTK) signaling. The selected candidate will be expected to work independently and stay up to date on the knowledge of principles and theories related to new and emerging technologies. The selected candidate will be developed as a functional area representative and leader on project teams.

Responsibilities include but are not limited to:

  • Multi-color flow panel design
  • Cell culture of primary hematopoietic cells including isolation, activation, and cryopreservation
  • T cell subset characterization using flow cytometry
  • Vector construction and engineering to modulate expression
  • Lentiviral vector construction and generation
  • RTK signaling analysis by Western blotting and other related approaches

Position Qualifications:

Education Minimum Requirement:

  • PhD in Immunology OR
  • MS in related Biological Sciences with a minimum of four (4) years of the experience in multicolor flow cytometry and primary lymphocyte culture

Required Experience and Skills:

  • Expertise in multi-color flow panel design and immunophenotyping of human Peripheral Blood Monocytic Cell (PBMCs) lineage and T cell differentiation subsets
  • Expertise of tools of flow cytometry data analysis, such as FlowJo
  • Experienced in primary lymphocyte isolation and culture.
  • Expertise in immunological assays related to T cell signaling and cellular functions.

Preferred Experience and Skills:

  • Vector construction and engineering to modulate expression
  • Lentiviral vector construction and generation
  • Expertise of Western blotting and RTK signaling study
  • Familiar with omics databases and bioinformatics tools;
  • Experience with cell engineering (e.g. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR))

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are…

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products. 

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development. 

What we look for…

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth. 





In accordance with Managers’ Policy – Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor

Secondary Language(s) Job Description: NA

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We are an equal opportunity employer, Minority/Female/Disability/Veteran — proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully 

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status: Regular

Relocation: Domestic

VISA Sponsorship:

Travel Requirements: No Travel Required

Flexible Work Arrangements: Not Specified

Shift: Not Indicated

Valid Driving License: No

Hazardous Material(s): E Coli, biohazard, DMSO

Number of Openings: 1

Requisition ID: R47390

Please apply via recruiter’s website.