Centers of Research Excellence
Ohio State University Comprehensive Cancer Center
Pelotonia Institute for Immuno-Oncology
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) is seeking candidates for the position of Group Leader in the Pelotonia Institute for Immuno-Oncology (PIIO). This is an excellent opportunity for a proven leader and innovator with an active and established research program to join the PIIO’s executive team in accelerating the pace for discovery and translation in immuno-oncology (IO).
The PIIO is a comprehensive bench-to-bedside research initiative focused on developing life-saving cancer immunotherapy breakthroughs at all levels – from prevention to treatment to survivorship. Established by a pledge of more than $100 million from Pelotonia (pelotonia.org) and the OSUCCC – James, the PIIO represents Ohio State University’s commitment to grow the exciting area of immuno-oncology. Led by founding director and renowned immunologist Zihai Li, MD, PhD, the PIIO builds upon a rich portfolio of active investigator-initiated IO clinical trials being conducted at the OSUCCC – James. Its external advisory board is comprised of multiple world leaders in the field of IO including Drs. Lisa Butterfield, Lieping Chen, Carl June, Miriam Merad, Robert Schreiber, and Cassian Yee (cancer.osu.edu/PIIO). The Institute’s initiatives include recruiting outstanding researchers; developing first-in-class, first-in-man IO agents; training the next generation of IO scientists; and fostering high-impact and holistic partnerships.
The successful candidate will serve as a senior member of the PIIO’s leadership team, directing one of the Institute’s four interconnected Centers of Research Excellence:
Cancer Immuno-Genomics: a program conducted in partnership with Nationwide Children’s Hospital which involves understanding the relationship between cancer genomics and immune evasion and includes epigenetics, neo-antigen vaccine, epitope prediction, TCR repertoire analysis, HLA typing, and CRISPR screening;
- Cell Therapy: where immune cells are collected from a patient’s blood, engineered, and returned to that patient to target and eradicate cancer and includes adoptive cell therapy with T cells and natural killer cells;
· Systems Immuno-Oncology: which seeks a better understanding of cellular systems to create more efficient and effective immunological tools to fight cancer and includes immune regulation, microbiome, NK and T cell biology, and tumor microenvironment;
- Translational Immuno-Oncology: an area that focuses on transforming immuno-oncology discoveries into new or improved cancer treatments applicable at patient bedsides. This team works with the Drug Development Institute at the OSUCCC – James on developing new drug therapies.
The successful candidate – while maintaining an independent research program and obtaining extramural funding – will recruit, retain, and further develop strong investigators committed to advancing their Center of Research Excellence; set the strategic vision for growing its Center’s research initiatives; and develop and enhance collaborative partnerships both internally and externally. The Group Leader will work closely with leaders of the PIIO’s Immuno-Informatics (Data Science) Group, where big data and quantitative science are used to improve immuno-oncology research and includes machine learning, neo-antigen discovery, spatial statistics, etc.; and Immune Monitoring and Discovery Platform, which is backed by a new facility with technology that allows scientists to get a 360-degree view—down to the single-cell level—of what happens in the immune system during treatment with immuno-oncology agents.
Candidates will have access to state-of-the-art laboratory spaces; cutting-edge core research facilities (Spectrum Flow Cytometry, Time-of-Flight Mass Cytometry, Multiplex Histology, Single Cell Technology, GMP Facility for Cell Therapy, Antibody Engineering Facility, Immuno-Informatics and more); a competitive salary commensurate with experience, and ample start-up funding.
Applicants must hold advanced degrees such as a MD, DVM, PharmD, PhD, or MD/PhD. The ideal candidate will have a national and international reputation in their field and significant independent research experience with both historical and current federal funding of research projects as a Principal Investigator. The successful candidate is expected to maintain an extramurally funded research program, perform collaborative research with others, participate in graduate and medical education, and must be board-certified and meet medical licensure requirements in Ohio for those also pursuing a clinical position. The successful candidate will become faculty at the rank of either Associate Professor or Full Professor. The Ohio State University is an EOE/AA/M/F/D/V employer.
To Apply: Send cover letter, Curriculum Vitae, 2-3 page description of current and future research interests, and contact information for three references to the office of the director of the PIIO, Zihai Li, MD, PhD, via Tamra Brooks at email@example.com.