Senior Scientist Antibody Developability
UK – Hertfordshire – Stevenage
GlaxoSmithKline (GSK) is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
Biopharm Discovery is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation, to molecular engineering and biological and physiochemical profiling. Within the Biopharm Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.
We are currently seeking an enthusiastic, dynamic and self-motivated Scientist to join the Developability Modernisation group within MDE. The role will be primarily lab focused. It will involve developing, validating and implementing high throughput methods to rapidly profile large panels of biopharmaceuticals and performing interpretations on the generated data. These activities will focus on predictability of molecule characteristics through the manufacturing process. You will have the opportunity to build capability in automated workflows.
The successful candidate will have experience in protein engineering, expression & purification, preferably with an industrial emphasis. Whilst experience of analytical techniques to characterize proteins, such as mass spectrometry, light scattering, SEC-HPLC, spectroscopy etc. is desired, an understanding of microfluidics would be advantageous. Although predominantly lab-based, the role also involves important aspects of verbal and written communication and requires good organisation as well as a broader scientific knowledge and the ability to collaborate both within and outside of GSK. Both individual and team working are required and therefore the role will suit a scientist with good interpersonal skills, abilities in data analytics and self-motivation.
Closing Date for Applications: Thursday 31st October 2019 COB
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
We are looking for professionals with these required skills to achieve our goals:
- PhD or equivalent experience in analytical biochemistry, biochemical engineering, bioprocessing or a related discipline
- Experience in mammalian protein expression and purification
- An understanding of screening biopharmaceuticals using analytical methods in a high throughput manner
- Experience of improving existing and developing novel high throughput methods/assays
- Use and design of automated solutions to scientific workflows
- Good understanding of antibody sequence/structure-function relationship
- Good analytical and data interpretation skills
- Strong written and verbal communication skills
- Strong attention to detail in experimental setup; capability to multitask and run multiple experiments in parallel, good organisational and prioritisation skills
- Strong computing skills for data handling, reporting (written & oral) and experimental lab book write-ups
- Quick adaptability in new scientific areas, working across teams and the use of lab instrumentation
- Ability to review and assimilate new information effectively
If you have the following characteristics, it would be a plus:
- Previous experience of the R&D environment, biopharmaceutical process development and challenges for laboratory capabilities
- Experience of automated data analysis and/or visualization software
- Experience of developing miniaturized assays
- A strong understanding of microfluidic approaches
Our values and expectations are at the heart of everything we do and form an important part of our culture.
These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness
GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. We discover, make and market life-enhancing products that are used by millions of people around the world, helping them to do more, feel better and live longer. We have 3 primary areas of business in pharmaceuticals, vaccines and consumer healthcare. We have offices in more than 115 countries, major research centers in the UK, USA, Spain, Belgium and China and an extensive manufacturing network with 87 sites globally. Our three strategic priorities are to grow a diversified global business, deliver products of value, and to simplify our operating model.
As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.
We’re open to all talent – whatever your gender, disability, marital status, religion or belief, age, race, sexual orientation, ethnic or national origin.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Please don’t hesitate to contact us if you’d like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email firstname.lastname@example.org
As you apply, we will ask you to share some personal information which is voluntary. This will be used to help us understand how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information, it is not used in any part of the selection process and we will treat your information confidentially and use it anonymously.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.