Are you passionate about target discovery, imaging technologies and machine learning?
Do you have experience working with human disease models, and are you eager to apply your imaging expertise in an organisation that is committed to developing game-changing therapies for patients with type 2 diabetes and cardiometabolic diseases?
Then join us as our new Senior Research Scientist.
About Novo Nordisk Research Centre Oxford (NNRCO)
Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. We employ more than 42,000 people in 80 countries and market our products in around 170 countries.
Novo Nordisk Research Centre Oxford (NNRCO) is Novo Nordisk’s Translational Research Unit focused on biology and target discovery across the broad spectrum of cardiometabolic disease in Oxford, United Kingdom. Our location in the heart of the University of Oxford medical campus enables two-way collaborations with some of the best medical scientists in the world. We use genetics, functional genomics, human-centric disease models and computational biology to develop an unparalleled understanding of cardiometabolic disease and deliver therapies that transform the lives of patients.
You can read more about Novo Nordisk Research Centre Oxford at: http://www.novonordisk.co.uk/about-novo-nordisk-in-uk/oxford-research-centre.html
About the Department
The Department of Discovery Technologies and Genomics has as its mission to establish and apply state-of-the-art genomics and screening technologies to discover and validate novel therapeutic targets for cardiometabolic diseases using human-centric in vitro approaches. Ultimately, our aim is to identify targets and key biology to discover new disruptive therapeutics.
The department is led by Carina Ämmälä, and consists of specialists, staff scientists and post-doctoral scientists. We are a dedicated, collaborative team, working within a variety of advanced technologies, including high throughput screening, high content imaging, single-cell sequencing, CRISPR editing, functional genomics, proteomics, peptidomics, and statistical modelling. Together, we share a passion for translational research and a desire to discover new scientific paths to improve the lives of patients.
In this position you will be responsible for setting strategic direction and building our imaging platform at NNRCO. Moreover, you will develop and optimize quantitative image-based assays and statistical and computational modelling tools.
To leverage the full potential of our imaging platform, you will work with your colleagues to automate analysis of image based phenotypic cellular assays for high throughput screening. Also, you will work closely with members of the computational biology department to develop and apply machine learning and large-scale data mining pipelines. Collaboration is key at the NNRCO, and you will work in multi-disciplinary matrix teams and will also be developing and leading your own projects. Likewise, it will be an important part of your role to establish and foster academic collaborations and external network in state-of-the-art cell-based imaging technologies
In addition, you will contribute as subject matter expert in the organisation. Specifically, you will be involved in developing a framework for data storage, management and knowledge sharing as it relates to imaging, within NNRCO and in Novo Nordisk globally. As a senior scientist, it will be part of your role to act as a role model, and to mentor junior team members in image-based methodologies to be self-reliant running assays. Indeed, in building our imaging platform it will be considered a success criterion that the technology can be passed on to your peers so to ensure long term sustainable imaging capability at NNRCO.
It will be expected that you think creatively and visionary apply your thinking to propose and lead research projects in the cardiometabolic research area. Candidates can expect recognition, empowerment and professional development aligned with the ambition of NNRCO.
You have a PhD. in life science or physics, along with significant hands on experience in use and analysis of imaging methodologies with good understanding of machine learning based analyses of cellular imaging, matlab, R, or Python other programming languages, Spotfire and Columbus software. Experience with optimization, validation and automation of cellular assays for high throughput screening is essential. Some experience working with larger projects will be considered an advantage.
You will be expected to work on multiple tasks or projects simultaneously and a high degree of self-motivation is needed. Collaboration, both internally and externally, is core in our work. Therefore, we are looking for a person who has excellent collaborative and communication skills and who is motivated by working alongside others and who is proactive in sharing knowledge and experiences. Moreover, you must be able to work with tight timelines and be comfortable working under pressure.
Excellent proficiency in English is a prerequisite.
Working at Novo Nordisk
At Novo Nordisk, we use our skills, dedication and ambition to help people with diabetes. We offer the chance to be part of a truly global work place, where passion and engagement are met with opportunities for professional and personal development.
For further information, please contact Director Carina Ämmälä on +44 782 460 6940
19th July 2020