Chemical Biological Centre (KBC) at Umeå University and Swedish University for Agricultural Sciences

Senior Research Engineer in toxicokinetics and computational chemistry

Umeå University, Department of Chemistry

Umeå, Sweden

We are looking for a senior research engineer for projects within the areas of toxicokinetics, pharmacokinetics, or computational chemistry and a special interest in chemicals and human health. You will work in a large network of scientists in a project aimed at developing models and systems for studying combination effects of chemicals and identifying endocrine disruptors. Our specific task is to develop models to be able to predict biological effects and estimate levels and distribution of chemicals in humans and other organisms. Application deadline is May 27, 2019.

Project
The project entitled “Risk modeling of mixtures of endocrine disrupting chemicals relevant to human exposure, using zebrafish (Danio rerio) embryo as model organism” aims to derive experimental data and models to improve our understanding of effects of combinations of chemicals. One objective is to develop refined methodology for risk assessment of complex mixtures based on the dose addition model and improved level estimate at target organ. New markers for exposure will be sought through genomics and metabolomics studies. Our part of the projects is primarily to develop so-called physiologically based toxicokinetic (PBTK) models with the purpose of producing time-resolved distribution data of chemicals in different organisms with a focus on zebrafish as a model organism. We will also develop data-driven models (machine learning and traditional statistical methods) to predict effects of chemicals on the thyroid system in particular. Large amounts of data will be generated in the project where we are responsible for model development and interpretation. We will collaborate with other research groups in the project to interpret data and report results.

Tasks
Your task will be to develop, establish, and use models for toxicokinetics with the aim of studying the distribution of chemicals in different organisms with a focus on zebrafish and humans. You will also work towards developing of machine learning methods with chemical and biological data aiming at predicting thyroid hormone related effects. You will collaborate with other research groups in the project to report results and share data. Results should be reported at scientific meetings and scientific journals. Cooperation and supervision of other employees in the research group is also part of the work.

Qualifications
To qualify for the position a PhD degree in chemistry, toxicology, pharmacology or biology, or equivalent is required as well as documented competence in English both written and spoken. You must also be structured, independent, ambitious, enthusiastic, and have the ability to collaborate with others within the area.

Documented experience in toxicokinetic/pharmacokinetic modeling (PK/TK, PBPK/PBTK), multivariate statistical methods and software such as R, Matlab, Python, KNIME, Berkley Madonna, GastroPlus, SimCyp, WinNonlin, and NONMEM is meriting. Postdoctoral experience is a merit.

Application
The application must contain a cover letter stating why you are interested in the position, a resume (CV), list of scientific publications, doctoral degree certificate, other relevant certificates and grades, and name and contact information for at least two reference persons.

You apply through our e-recruitment system. The application link is on this page: https://umu.mynetworkglobal.com/en/what:job/jobID:262001/. Log in and apply via the button at the bottom of the page. The deadline for applications is May 27, 2019.

Terms of employment
The position is permanent on a full-time basis with start as soon as possible. A probationary period may be applied.

Other information
Further information can be obtained from Professor Patrik Andersson, phone: +4690-786 5266, e-mail: patrik.andersson@umu.se.

About us
The Department of Chemistry is one of the largest departments within the Faculty of Science and Technology with approximately 200 employees, of which approximately 40 graduate students, and a strong and expanding research. The Department has three major research areas: Biological Chemistry, Environmental and Biogeochemistry, and Technical Chemistry. We are also a strong partner in the KBC, Chemical-Biological Center (in Swedish “Kemiskt Biologiskt Centrum”, KBC) – an interdisciplinary research centre for the life/natural sciences and medicine at Umeå University and the Swedish University of Agricultural Sciences. The centre is unique in its collaborative structure and offers an excellent scientific infrastructure with several core facilities and technical platforms. Our goal is to promote a positive, creative, and interdisciplinary environment for research combined with an excellent graduate and undergraduate education. You can find more information here: www.umu.se/en/kbc.

Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programmes, world leading research, and excellent innovation and collaboration opportunities. More than 4 000 employees and 30 000 students have already chosen Umeå University. We welcome your application!

Umeå University wants to offer an equal environment where open dialogue between people with different backgrounds and perspectives lay the foundation for learning, creativity and development. We welcome people with different backgrounds and experiences to apply for the current employment.

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Quote Reference: AN 2.2.1-686-19

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