Wellcome Trust Sanger Institute

Senior Research Assistant - Open Targets

Wellcome Sanger Institute

Cambridge, United Kingdom

The Garnett lab aims to identify new therapeutic approaches for the treatment of cancer by combining the use of advanced tissue cultures models, genetics, and functional genomics approaches.

We are now seeking a senior research assistant (SRA) to join our team working on an exciting new project in the field of immuno-oncology. This project aims to discover the mechanisms that can modulate the reactivity of T-cells to the tumour.

The position is laboratory based and will involve culturing 3D organoid cancer models and lymphocyte cultures, high-throughput drug testing, and performing CRISPR screens. The individual will be involved in research and development of new protocols, so will need to be adaptable to changing priorities and to work independently. It is expected that the successful candidate will be able to use their skills and experience to trouble shoot and innovate assays.

The senior research assistant will work as part of multidisciplinary and collaborative team. The project is funded by Open Targets, a private-public partnership between academia and industry, and is a collaboration between the Sanger Institute, the Netherlands Cancer Institute (PI: Dr. Emile Voest, MD PhD) and pharmaceutical companies as part of the Open Targets community.

Essential Skills
• A degree or equivalent relevant experience in molecular biology, cellular biology, or related discipline;
• Experience using advanced cell culture methods such as 3D cultures, organoids, or primary cultures;
• A wide range of molecular biology skills such as molecular cloning, the use of viability and apoptosis assays, Western blotting, flow cytometry, lentiviral production and microscopy;
• A track record of delivering complex scientific experiments to a high standard;
• Ability to deal with a wide variety of issues, should any arise, and to trouble shoot the vast majority of problems independently;
• Ability to co-ordinate collaborations with internal and external stakeholders;
• A self-motivated individual, adaptable and able to follow instructions accurately with attention to detail;
• Ability to work independently;
• Exceptional communication skills

Ideal Skills
• Experience in cancer biology and immunology;
• Experience in analysis of genomic data;
• Experience in high throughput imaging techniques;
• Experience performing CRISPR or RNAi screens.

Other information
Closing Date: 3rd November 2019

About Us
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog.

Our campus
Set across 130 acres, just outside of Cambridge, The Sanger Institute is located on the stunning Wellcome Genome Campus. Home to some of the world’s foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges.

Our benefits:
There’s an attractive benefits package on offer at the Genome Wellcome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site

Being part of the Genome Wellcome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events

To find out more about our Genome Wellcome Campus, see here.

We hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

About Open Targets
Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Please apply via recruiter’s website.