Job title: Senior Laboratory Research Scientist
Location: The Francis Crick Institute, Midland Road, London
Contract: Permanent – Full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 011726
We are looking for a highly experienced, enthusiastic and self-motivated Senior Laboratory Research Scientist who can work with semi-independence to oversee and manage the day to day running of the experimental side of our computational modelling lab. Primarily you will perform our in vitro micropatterning and microfluidic experiments for whilst collaborating with and/or training other lab members, with varying levels of wetlab experience. As such an ability to communicate and work closely with researchers across disciplines is essential. High proficiency with endothelial cells in culture, micropatterning and vascular microfluidic devices and microscopy required. Furthermore, experience in mouse retinal angiogenesis experiments such as the Oxygen Induced Retinopathy Mouse model is required for involvement in an ongoing research project. The successful candidate will report directly to Dr. Bentley, Head of the Cellular Adaptive Behaviour Laboratory based at the Francis Crick Institute. For more information on the kind of work we do see https://www.crick.ac.uk/research/labs/katie-bentley.
This is an entirely wetlab-based project, where the successful candidate will be responsible for investigating the behaviour of human vascular endothelial cells (ECs) under varying growth factor conditions and spatial constraints, by using cutting-edge micropatterning techniques. Whilst constrained in pre-defined patterns, vascular ECs exhibit markedly altered shuffling and filopodia extension dynamics, which occurs normally in angiogenesis. The dynamics of these ECs, as well as being used to further refine our computational models and inform future directions for research, will also be used to provide insight into pathological retinal vascular topologies. Furthermore, the successful applicant will also be responsible for overseeing the administrative and scientific needs of the group, such as by ordering in new supplies, generating protocols and health and safety assessments or by training incoming members of the lab in relevant experimental techniques.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute is world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it to the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 12 September 2019 at 23:45.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
- Central London / London
- Camden / St Pancras / Kings Cross
- Experimental Biology
- Wet Lab
- Vascular Biology
- Senior Level Role
- In vitro
- In vivo
- Computational biology