Francis Crick Institute

Senior Laboratory Research Scientist - Proteomics

Francis Crick Institute

London, United Kingdom

Salary for this Role:

From £36,000 with benefits, subject to skills and experience.

Job Title:

Senior Laboratory Research Scientist – Proteomics
Reports to:

Mark Skehel
Closing Date:

04/Jun/2022 23.59 GMT
Job Description:

Job title: Senior Laboratory Research Scientist

Reporting to: Head of Proteomics

Contact term: This is a full-time, permanent position on Crick terms and conditions of employment.

Are you passionate about proteomic research and have experience implementing state-of-the-art biological mass spectrometry and proteomics technologies?

We have an exciting opportunity within the Proteomics Scientific Technology Platform (STP) at the Francis Crick Institute. Working in collaboration with Crick colleagues across key areas of research in Cancer, Development, Immunology, Infectious Disease, Neuroscience, Structural Biology and Synthetic Biology, the successful candidate will guide and advise researchers on the most effective ways the STP can contribute to research projects. This is a lab-based position, responsible for driving forward projects, from experimental design through sample preparation to data analysis.

The Proteomics STP houses a broad range of mass spectrometers including Thermo Scientific Orbitrap Eclipse Tribrid with FAIMS and ETD, Orbitrap Fusion Lumos, Q Exactive UHMR and Exploris 480, Waters SYNAPT G2Si HDMS, and Select Cyclic IMS and a Bruker timsTOF Pro. The role will focus on collaboration and joint experimental design, using the available mass spectrometry technologies to both qualitatively and quantitatively measure proteins. The successful candidate will be able to take initiative in projects, delivering results in a timely fashion. To be considered for this role the applicant must have >3 years hands-on experience of working in proteomics.

Key responsibilities
These include but are not limited to:

Planning of experiments, decision making regarding which techniques to employ, and independently executing collaborative experiments.
Undertaking both standard and bespoke proteomics experiments.
LC-MS/MS nanoUHPLC data acquisition, evaluation, and processing of raw data.
Communication of results to collaborators.
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:

Qualifications, experience and competencies:

A PhD or equivalent experience gained through working in a mass spectrometry laboratory, including basic and advanced proteomic sample handling and processing protocols, and familiarity with instrument maintenance requirements.
Direct experience with either the Thermo Scientific Orbitrap Tribrid platform or the Bruker timsTOF Pro.
Familiarity with data analysis software such as Proteome Discoverer, PEAKS, Mascot, MaxQuant, Spectronaut and Skyline.
Experience of independently organising and running projects.
Excellent communication, record keeping and problem-solving skills.
Ability to present your research at both internal and external meetings.
Ability to work confidently and independently, approaching research problems with initiative and flexibility.
Experience and competencies:

Experience with maintaining nanoLC, Orbitrap or Q-TOF instrumentation.
Familiarity with a range of advanced proteomic workflows and techniques (SILAC, TMT, DIA, PTM enrichment etc).
Experience in infectious diseases particularly Parasitology (specifically single-celled microorganisms of the plasmodium group)
Publication record demonstrating contribution using proteomics and mass spectrometry applications or methodology.
For informal queries on the role please contact Dr J. Mark Skehel by email:

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here:

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website:

Please apply via recruiter’s website.