Job title: Senior Laboratory Research Scientist
Location: The Francis Crick Institute, Midland Road, London
Contract: Fixed-term, 12 months
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 10808
We are searching for a Senior Laboratory Research Scientist to join the laboratory of Veni Papayannopoulos for one year initially, with a possibility of extension depending on project progress and performance. The researcher will be responsible for designing and conducting experiments, analysing data and producing reports. The successful candidate will undertake a project that aims to translate recent basic science discoveries towards novel therapies for inflammatory conditions. Despite the translation aspects, the candidate will be able to be part of a small but very active research team that conducts exciting basic science research.
The goals of the project will be to characterize the role and mechanism of action of novel anti-inflammatory factors in various mouse models of disease. This will involve both in vitro experiments with cultured immune cells and in vivo mouse work aiming at developing novel therapeutics for the treatment of inflammatory conditions and cancer.
Our lab’s expertise centers around neutorphils and the mechansism that regulate their antimicrobial strategies and communication with other immune cells. In recent years our work has highlighted novel mechanisms that allow neutrophils to regulate inflammation and essentially their recruitment and activation. One of these mechanisms involves the release of neutrophil extracellular traps, web-like structures that can activate immune cells such as macrophages and dendritic cells to promote inflammation and autoimmunity, or participate in pro-tumorigenic processes that lead to cancer. We now understand how NETs are released and are beginning to understand how the molecular mechanisms that promotes their various functions. This project aims developing new strategies for interfering with these mechanisms in a specific manner that may lead to new treatments for a variety of NET-related conditions.
The candidate will have to be well, organised, highly capable and enthusiastic and able to drive such a project independently.
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
- If you are interested in applying for this role, please apply via our website.
- The closing date for applications is 13 June 2019 at 23:30.
- All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.