Wellcome Trust Sanger Institute

Senior Database Curator - Cancer Genetics

Wellcome Sanger Institute

Cambridge, United Kingdom

Scientist Curator – Genetic Drivers of Cancer
We are seeking a motivated and experienced scientist in cancer molecular biology and genetics to lead the expansion and curation of the Cancer Gene Census at the Wellcome Sanger Institute within COSMIC, a database of genetic mutations in cancer, a major resource in cancer research, widely used across informatics, diagnostic and pharmaceutical industries.

The Opportunity
COSMIC is working with Open Targets to expand the world’s most comprehensive description of the genes causing human cancer, the Cancer Gene Census. This is an exciting position within the COSMIC team, where you will have the opportunity to explore & interpret a wide range of literature, database and analytic resources to create a complete landscape of genetic dysfunctions across all cancer types and explain which molecular mechanisms are most important in development of these diseases. Our first aim is to expand the Cancer Gene Census with new genes, and to generate full descriptive coverage of all Census genes with evidence of oncogenic activity. The Cancer Gene Census is frequently cited in publications and regularly used as a key data source in cancer genome analytics and databases; this project extends this high-profile resource, offering multiple opportunities for very citeable publications. This position is available for 18 months with a possibility of extension.

About you
You will work together with COSMIC scientific team, bringing a range of analytic, curation and literature techniques to describe the oncogenic impact of genes implicated in cancer. During this project, you will have substantial opportunities for learning and development, working closely with informaticians and cancer scientists in COSMIC, in the Sanger Institute, and software/database developers in Open Targets; informatic assistance is available to candidates with strong scientific expertise.

Essential Skills
• PhD in Biosciences or Bioinformatic discipline (or equivalent experience)
• Substantial knowledge and experience of cancer genetics and biology
• Experience with scientific literature and ability to interpret and summarise experimental findings
• Self-motivated, able to work independently and organise own workload
• Good communication skills both oral and written

Ideal Skills
• Experience of relational databases
• Data handling skills

Other information
COSMIC

A revolution is underway in health informatics, with genetics increasingly important in understanding human health and disease. COSMIC, a database of genetic mutations in cancer, is a major resource in cancer research, used by over 3000 scientists every day across the informatics, diagnostic and pharmaceutical industries. We are expanding rapidly and developing a range of new services to support multiple academic and industrial research efforts.

Please include your CV and cover letter outlining your suitability for the position in your application.

Candidates will be reviewed on an ongoing basis and the advert may be withdrawn when sufficient applications have been received. As such, we encourage early application.

About Us
The Wellcome Sanger Institute is a world leading genomics research centre. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. Our findings are used to improve health and to understand life on Earth. Find out more at www.sanger.ac.uk or follow us on Twitter, Facebook, LinkedIn, Youtube and on our Blog.

Our benefits:
There’s an attractive benefits package on offer at the Wellcome Genome Campus. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement.
As well as the usual benefits you would expect, we go much further:
• 25 days annual leave (extra 1 day to a maximum of 30 days for every year you work)
• Auto-enrolment into a generous Group Defined Contribution Pension Scheme, with enhanced company contribution (for more information, see our Pensions page)
• Up to 2 days annual paid volunteering leave
• Up to 10 days paid Emergency Carers Leave per year
• Family friendly environment including options for flexible and part-time working, an on-site Workplace Nursery salary Sacrifice Schemes for pre-school children and Summer holiday club
• Life Assurance Cover and a Group Income Protection Scheme (if on a contract of 12 months or more)
• Enhanced maternity leave and parental leave
• Access to substantial number of courses and training events onsite
• Private Healthcare Scheme (after 6 months service)
• Eyecare and Dental payment plans
• Concessions and discounts from our corporate perks site

Being part of the Wellcome Genome Campus you will be part of the beautiful working environment with an impressive range of benefits, services and facilities also including:
• Free bus service to and from Campus, covering various routes around Cambridge, Saffron Walden and surrounding villages
• A car-share initiative
• Free parking
• A number of on-site venues where you can meet, eat and socialise with colleagues
• A thriving Sports and Social Club which provides members with subsidised access to a gym, tennis courts, sports hall, fitness classes and a vibrant social calendar of events
Find out more about our Wellcome Genome Campus.

We have recently been awarded an Athena SWAN Silver Award. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

About Open Targets
Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Bristol Myers Squibb (BMS), Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Please apply via recruiter’s website.