Genentech, Inc.

Scientist, Structural Biology

Genentech, Inc.

South San Francisco, CA, United States

Join a Team that Lives to Improve Lives
People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what’s possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in our South San Francisco, CA headquarters:

Scientist, Structural Biology


We have an opportunity for a talented structural biologist with expertise in X-ray crystallography and cryo-electron microscopy to join the Genentech Structural Biology Department as a Scientist. The successful candidate will lead the structural pursuit of diverse drug discovery targets as well as their own independent research.

The role applies structure-based drug design to protein complexes of importance to human diseases and crystallography and/or cryoEM as tools to dissect complex biology and intermolecular interactions. The candidate will work embedded in cross-functional teams; therefore, prior successful collaborations are expected.

The Genentech Structural Biology Department integrates macromolecular crystallography, cryoEM, and NMR spectroscopy to drive drug discovery and uncover fundamental biology. We explore the structural and functional properties of proteins of therapeutic interest and their interactions with diverse ligands. Our group designs constructs, purifies proteins, and then analyzes their structures and molecular interactions. We collaborate with scientists throughout the Research organization to advance both traditional “small molecule” and protein-based drug discovery as well as to pursue basic research questions regarding structure and function.

Who You Are

Macromolecular structural biologist with outstanding experience in all aspects of structure determination, from construct design through structure refinement, interested in joining a multi-disciplinary structural biology department, to pursue drug design and to perform groundbreaking research.


• Ph.D. in structural biology, biophysics, biochemistry or related discipline, relevant post doctoral experience, and 0-5 years additional experience as an independent scientific investigator or group leader.
• Knowledge of protein purification, fundamental biochemistry, and a strong record of impactful publications as well as significant technical expertise in determining X-ray crystal and cryoEM structures is required.
• Prior experience working with protein:ligand complexes for mechanistic studies or drug discovery and/or programming skills are highly desirable.
• Facility with standard software related to structure determination and data presentation is expected.
• As this position interfaces with multiple groups at Genentech, high quality verbal, written, and presentation skills are essential.

A Job with Benefits Beyond the Benefits
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the “Apply online” button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

Please apply via recruiter’s website.